Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases

[Image: see text] The DNAJB1–PRKACA oncogenic gene fusion results in an active kinase enzyme, J-PKAcα, that has been identified as an attractive antitumor target for fibrolamellar hepatocellular carcinoma (FLHCC). A high-throughput assay was used to identify inhibitors of J-PKAcα catalytic activity...

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Detalles Bibliográficos
Autores principales: Du, Lin, Wilson, Brice A. P., Li, Ning, Shah, Rohan, Dalilian, Masoumeh, Wang, Dongdong, Smith, Emily A., Wamiru, Antony, Goncharova, Ekaterina I., Zhang, Ping, O’Keefe, Barry R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616853/
https://www.ncbi.nlm.nih.gov/pubmed/37843072
http://dx.doi.org/10.1021/acs.jnatprod.3c00394

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