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FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review
Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research. Accumulating studies have reported that N6-methy...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616962/ https://www.ncbi.nlm.nih.gov/pubmed/37916161 http://dx.doi.org/10.3389/fonc.2023.1241357 |
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author | Ren, Xiangqing Tang, Xiaolong Huang, Tian Hu, Zenan Wang, Yuping Zhou, Yongning |
author_facet | Ren, Xiangqing Tang, Xiaolong Huang, Tian Hu, Zenan Wang, Yuping Zhou, Yongning |
author_sort | Ren, Xiangqing |
collection | PubMed |
description | Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research. Accumulating studies have reported that N6-methyladenosine is the most abundant epigenetic modification in eukaryotes. N6-methyladenosine plays an essential role in regulating RNA expression and metabolism, including splicing, translation, stability, decay, and transport. FTO, the earliest demethylase discovered to maintain the balance of N6-adenosine methylation, is abnormally expressed in many tumors. In this review, we discuss the molecular structure and substrate selectivity of FTO. we focus on the role of FTO in gastrointestinal tumor proliferation, migration, invasion, apoptosis, autophagy, immune microenvironment, and its molecular mechanisms. We also discuss its potential in the treatment of gastrointestinal cancers. |
format | Online Article Text |
id | pubmed-10616962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106169622023-11-01 FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review Ren, Xiangqing Tang, Xiaolong Huang, Tian Hu, Zenan Wang, Yuping Zhou, Yongning Front Oncol Oncology Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research. Accumulating studies have reported that N6-methyladenosine is the most abundant epigenetic modification in eukaryotes. N6-methyladenosine plays an essential role in regulating RNA expression and metabolism, including splicing, translation, stability, decay, and transport. FTO, the earliest demethylase discovered to maintain the balance of N6-adenosine methylation, is abnormally expressed in many tumors. In this review, we discuss the molecular structure and substrate selectivity of FTO. we focus on the role of FTO in gastrointestinal tumor proliferation, migration, invasion, apoptosis, autophagy, immune microenvironment, and its molecular mechanisms. We also discuss its potential in the treatment of gastrointestinal cancers. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10616962/ /pubmed/37916161 http://dx.doi.org/10.3389/fonc.2023.1241357 Text en Copyright © 2023 Ren, Tang, Huang, Hu, Wang and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Ren, Xiangqing Tang, Xiaolong Huang, Tian Hu, Zenan Wang, Yuping Zhou, Yongning FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
title | FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
title_full | FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
title_fullStr | FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
title_full_unstemmed | FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
title_short | FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
title_sort | fto plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616962/ https://www.ncbi.nlm.nih.gov/pubmed/37916161 http://dx.doi.org/10.3389/fonc.2023.1241357 |
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