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In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

BACKGROUND: Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens in organoids could link genetic perturbations with parallel transcriptomic rea...

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Detalles Bibliográficos
Autores principales:	Liang, Junbo, Wei, Jinsong, Cao, Jun, Qian, Jun, Gao, Ran, Li, Xiaoyu, Wang, Dingding, Gu, Yani, Dong, Lei, Yu, Jia, Zhao, Bing, Wang, Xiaoyue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617096/ https://www.ncbi.nlm.nih.gov/pubmed/37907970 http://dx.doi.org/10.1186/s13059-023-03084-8

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