Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease

BACKGROUND: The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer disease (LOAD), but the associated molecular mechanisms, particularly with respect to the high-risk APOE4/4 genotype, are not well understood. For this purpose, we developed a multicellular isogenic model o...

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Detalles Bibliográficos
Autores principales: Haferkamp, Undine, Hartmann, Carla, Abid, Chaudhry Luqman, Brachner, Andreas, Höchner, Alevtina, Gerhartl, Anna, Harwardt, Bernadette, Leckzik, Selin, Leu, Jennifer, Metzger, Marco, Nastainczyk-Wulf, Marina, Neuhaus, Winfried, Oerter, Sabrina, Pless, Ole, Rujescu, Dan, Jung, Matthias, Appelt-Menzel, Antje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617216/
https://www.ncbi.nlm.nih.gov/pubmed/37907966
http://dx.doi.org/10.1186/s12987-023-00471-y

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