Cargando…

The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study

BACKGROUND: Prior studies suggest that sedentary behavior is a well-known risk factor for cardiometabolic diseases. However, the longitudinal association between overall siting time and kidney function decline is not known. MATERIAL/METHODS: We performed a nationwide prospective cohort study in indi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Peng, Zhao, Zhiyun, Huang, Li, Zou, Huajie, Meng, Xiaoyu, Kan, Ranran, Yu, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617246/
https://www.ncbi.nlm.nih.gov/pubmed/37885172
http://dx.doi.org/10.12659/MSM.941111
_version_ 1785129567091949568
author Yu, Peng
Zhao, Zhiyun
Huang, Li
Zou, Huajie
Meng, Xiaoyu
Kan, Ranran
Yu, Xuefeng
author_facet Yu, Peng
Zhao, Zhiyun
Huang, Li
Zou, Huajie
Meng, Xiaoyu
Kan, Ranran
Yu, Xuefeng
author_sort Yu, Peng
collection PubMed
description BACKGROUND: Prior studies suggest that sedentary behavior is a well-known risk factor for cardiometabolic diseases. However, the longitudinal association between overall siting time and kidney function decline is not known. MATERIAL/METHODS: We performed a nationwide prospective cohort study in individuals aged more than 40 years enrolled in the China Cardiometabolic Disease and Cancer Cohort (4C) study. A total of 132 123 individuals were included in this study. Sitting time was measured with the short version of the International Physical Activity Questionnaire (IPAQ). Kidney function decline was defined as an eGFR <60 mL/min/1.73 m(2) or more than a 30% decrease in eGFR from baseline. Multivariate Cox proportional hazards regression analyses were conducted to estimate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of the relation between kidney function decline and sitting time. RESULTS: During a mean follow-up of 3.8 years, 3890 (2.9%) participants experienced kidney function decline. Longer sitting time was significantly associated with the risk of kidney function decline (aHR, 1.136; 95% CI, 1.036–1.247, P=0.007, comparing participants with baseline sitting time in the lowest quartile with those in the highest quartile) after adjustment for potential confounders. CONCLUSIONS: Longer sitting time was independently and prospectively associated with a higher risk of kidney function decline. Sedentary behavior might represent a modifiable risk factor for chronic kidney disease (CKD) prevention.
format Online
Article
Text
id pubmed-10617246
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-106172462023-11-01 The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study Yu, Peng Zhao, Zhiyun Huang, Li Zou, Huajie Meng, Xiaoyu Kan, Ranran Yu, Xuefeng Med Sci Monit Clinical Research BACKGROUND: Prior studies suggest that sedentary behavior is a well-known risk factor for cardiometabolic diseases. However, the longitudinal association between overall siting time and kidney function decline is not known. MATERIAL/METHODS: We performed a nationwide prospective cohort study in individuals aged more than 40 years enrolled in the China Cardiometabolic Disease and Cancer Cohort (4C) study. A total of 132 123 individuals were included in this study. Sitting time was measured with the short version of the International Physical Activity Questionnaire (IPAQ). Kidney function decline was defined as an eGFR <60 mL/min/1.73 m(2) or more than a 30% decrease in eGFR from baseline. Multivariate Cox proportional hazards regression analyses were conducted to estimate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of the relation between kidney function decline and sitting time. RESULTS: During a mean follow-up of 3.8 years, 3890 (2.9%) participants experienced kidney function decline. Longer sitting time was significantly associated with the risk of kidney function decline (aHR, 1.136; 95% CI, 1.036–1.247, P=0.007, comparing participants with baseline sitting time in the lowest quartile with those in the highest quartile) after adjustment for potential confounders. CONCLUSIONS: Longer sitting time was independently and prospectively associated with a higher risk of kidney function decline. Sedentary behavior might represent a modifiable risk factor for chronic kidney disease (CKD) prevention. International Scientific Literature, Inc. 2023-10-27 /pmc/articles/PMC10617246/ /pubmed/37885172 http://dx.doi.org/10.12659/MSM.941111 Text en © Med Sci Monit, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Yu, Peng
Zhao, Zhiyun
Huang, Li
Zou, Huajie
Meng, Xiaoyu
Kan, Ranran
Yu, Xuefeng
The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
title The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
title_full The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
title_fullStr The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
title_full_unstemmed The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
title_short The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
title_sort impact of sedentary behavior on renal function decline in 132,123 middle aged and older adults: a nationwide cohort study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617246/
https://www.ncbi.nlm.nih.gov/pubmed/37885172
http://dx.doi.org/10.12659/MSM.941111
work_keys_str_mv AT yupeng theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT zhaozhiyun theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT huangli theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT zouhuajie theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT mengxiaoyu theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT kanranran theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT yuxuefeng theimpactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT yupeng impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT zhaozhiyun impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT huangli impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT zouhuajie impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT mengxiaoyu impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT kanranran impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy
AT yuxuefeng impactofsedentarybehavioronrenalfunctiondeclinein132123middleagedandolderadultsanationwidecohortstudy