Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla(SHV-12), leading to bla(S...

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Detalles Bibliográficos
Autores principales: Cui, Qiaozhen, Wang, Chen, Wang, Qichen, Qin, Juanxiu, Li, Min, Ding, Baixing, Shen, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617341/
https://www.ncbi.nlm.nih.gov/pubmed/37877674
http://dx.doi.org/10.3201/eid2911.230830
Descripción
Sumario:We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla(SHV-12), leading to bla(SHV-12) overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.

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