Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla(SHV-12), leading to bla(S...

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Detalles Bibliográficos
Autores principales: Cui, Qiaozhen, Wang, Chen, Wang, Qichen, Qin, Juanxiu, Li, Min, Ding, Baixing, Shen, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617341/
https://www.ncbi.nlm.nih.gov/pubmed/37877674
http://dx.doi.org/10.3201/eid2911.230830
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author Cui, Qiaozhen
Wang, Chen
Wang, Qichen
Qin, Juanxiu
Li, Min
Ding, Baixing
Shen, Zhen
author_facet Cui, Qiaozhen
Wang, Chen
Wang, Qichen
Qin, Juanxiu
Li, Min
Ding, Baixing
Shen, Zhen
author_sort Cui, Qiaozhen
collection PubMed
description We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla(SHV-12), leading to bla(SHV-12) overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.
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spelling pubmed-106173412023-11-01 Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae Cui, Qiaozhen Wang, Chen Wang, Qichen Qin, Juanxiu Li, Min Ding, Baixing Shen, Zhen Emerg Infect Dis Research Letter We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla(SHV-12), leading to bla(SHV-12) overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance. Centers for Disease Control and Prevention 2023-11 /pmc/articles/PMC10617341/ /pubmed/37877674 http://dx.doi.org/10.3201/eid2911.230830 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Cui, Qiaozhen
Wang, Chen
Wang, Qichen
Qin, Juanxiu
Li, Min
Ding, Baixing
Shen, Zhen
Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
title Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
title_full Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
title_fullStr Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
title_full_unstemmed Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
title_short Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
title_sort ceftazidime/avibactam resistance in carbapenemase-producing klebsiella pneumoniae
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617341/
https://www.ncbi.nlm.nih.gov/pubmed/37877674
http://dx.doi.org/10.3201/eid2911.230830
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