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Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia
Melioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Au...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617349/ https://www.ncbi.nlm.nih.gov/pubmed/37877500 http://dx.doi.org/10.3201/eid2911.230951 |
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author | Smith, Simon Marquardt, Tonia Jennison, Amy V. D’Addona, Andrew Stewart, James Yarwood, Trent Ho, Jennifer Binotto, Enzo Harris, Julian Fahmy, Mark Esmonde, Juliet Richardson, Megan Graham, Rikki M.A. Gair, Richard Ariotti, Lawrence Preston-Thomas, Annie Rubenach, Sally O’Sullivan, Siobhan Allen, Darren Ragh, Thomas Grayson, Sachjuan Manoy, Sophie Warner, Jeffery M. Meumann, Ella M. Robson, Jennifer M. Hanson, Josh |
author_facet | Smith, Simon Marquardt, Tonia Jennison, Amy V. D’Addona, Andrew Stewart, James Yarwood, Trent Ho, Jennifer Binotto, Enzo Harris, Julian Fahmy, Mark Esmonde, Juliet Richardson, Megan Graham, Rikki M.A. Gair, Richard Ariotti, Lawrence Preston-Thomas, Annie Rubenach, Sally O’Sullivan, Siobhan Allen, Darren Ragh, Thomas Grayson, Sachjuan Manoy, Sophie Warner, Jeffery M. Meumann, Ella M. Robson, Jennifer M. Hanson, Josh |
author_sort | Smith, Simon |
collection | PubMed |
description | Melioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Australia. All the children had participated in a single-day sporting event during the dry season in a tropical region of Australia, and all had limited cutaneous disease. All case-patients had an adverse reaction to oral trimethoprim/sulfamethoxazole treatment, necessitating its discontinuation. We describe the clinical features, environmental sampling, genomic epidemiologic investigation, and public health response to the outbreak. Management of this outbreak shows the potential benefits of making melioidosis a notifiable disease. The approach used could also be used as a framework for similar outbreaks in the future. |
format | Online Article Text |
id | pubmed-10617349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-106173492023-11-01 Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia Smith, Simon Marquardt, Tonia Jennison, Amy V. D’Addona, Andrew Stewart, James Yarwood, Trent Ho, Jennifer Binotto, Enzo Harris, Julian Fahmy, Mark Esmonde, Juliet Richardson, Megan Graham, Rikki M.A. Gair, Richard Ariotti, Lawrence Preston-Thomas, Annie Rubenach, Sally O’Sullivan, Siobhan Allen, Darren Ragh, Thomas Grayson, Sachjuan Manoy, Sophie Warner, Jeffery M. Meumann, Ella M. Robson, Jennifer M. Hanson, Josh Emerg Infect Dis Synopsis Melioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Australia. All the children had participated in a single-day sporting event during the dry season in a tropical region of Australia, and all had limited cutaneous disease. All case-patients had an adverse reaction to oral trimethoprim/sulfamethoxazole treatment, necessitating its discontinuation. We describe the clinical features, environmental sampling, genomic epidemiologic investigation, and public health response to the outbreak. Management of this outbreak shows the potential benefits of making melioidosis a notifiable disease. The approach used could also be used as a framework for similar outbreaks in the future. Centers for Disease Control and Prevention 2023-11 /pmc/articles/PMC10617349/ /pubmed/37877500 http://dx.doi.org/10.3201/eid2911.230951 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Synopsis Smith, Simon Marquardt, Tonia Jennison, Amy V. D’Addona, Andrew Stewart, James Yarwood, Trent Ho, Jennifer Binotto, Enzo Harris, Julian Fahmy, Mark Esmonde, Juliet Richardson, Megan Graham, Rikki M.A. Gair, Richard Ariotti, Lawrence Preston-Thomas, Annie Rubenach, Sally O’Sullivan, Siobhan Allen, Darren Ragh, Thomas Grayson, Sachjuan Manoy, Sophie Warner, Jeffery M. Meumann, Ella M. Robson, Jennifer M. Hanson, Josh Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia |
title | Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia |
title_full | Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia |
title_fullStr | Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia |
title_full_unstemmed | Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia |
title_short | Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia |
title_sort | clinical manifestations and genomic evaluation of melioidosis outbreak among children after sporting event, australia |
topic | Synopsis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617349/ https://www.ncbi.nlm.nih.gov/pubmed/37877500 http://dx.doi.org/10.3201/eid2911.230951 |
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