Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana

GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre–extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasi...

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Detalles Bibliográficos
Autores principales: Modongo, Chawangwa, Barilar, Ivan, Wang, Qiao, Molefi, Tuduetso, Makhondo, Topo, Niemann, Stefan, Shin, Sanghyuk S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617350/
https://www.ncbi.nlm.nih.gov/pubmed/37877680
http://dx.doi.org/10.3201/eid2911.230987
Descripción
Sumario:GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre–extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.

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