Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana

GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre–extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasi...

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Detalles Bibliográficos
Autores principales: Modongo, Chawangwa, Barilar, Ivan, Wang, Qiao, Molefi, Tuduetso, Makhondo, Topo, Niemann, Stefan, Shin, Sanghyuk S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617350/
https://www.ncbi.nlm.nih.gov/pubmed/37877680
http://dx.doi.org/10.3201/eid2911.230987
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author Modongo, Chawangwa
Barilar, Ivan
Wang, Qiao
Molefi, Tuduetso
Makhondo, Topo
Niemann, Stefan
Shin, Sanghyuk S.
author_facet Modongo, Chawangwa
Barilar, Ivan
Wang, Qiao
Molefi, Tuduetso
Makhondo, Topo
Niemann, Stefan
Shin, Sanghyuk S.
author_sort Modongo, Chawangwa
collection PubMed
description GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre–extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.
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spelling pubmed-106173502023-11-01 Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana Modongo, Chawangwa Barilar, Ivan Wang, Qiao Molefi, Tuduetso Makhondo, Topo Niemann, Stefan Shin, Sanghyuk S. Emerg Infect Dis Research Letter GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre–extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment. Centers for Disease Control and Prevention 2023-11 /pmc/articles/PMC10617350/ /pubmed/37877680 http://dx.doi.org/10.3201/eid2911.230987 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Modongo, Chawangwa
Barilar, Ivan
Wang, Qiao
Molefi, Tuduetso
Makhondo, Topo
Niemann, Stefan
Shin, Sanghyuk S.
Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
title Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
title_full Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
title_fullStr Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
title_full_unstemmed Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
title_short Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana
title_sort tuberculosis variant with rifampin resistance undetectable by xpert mtb/rif, botswana
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617350/
https://www.ncbi.nlm.nih.gov/pubmed/37877680
http://dx.doi.org/10.3201/eid2911.230987
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