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Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021
Pandoraea spp. are gram-negative, nonfermenting rods mainly known to infect patients with cystic fibrosis (CF). Outbreaks have been reported from several CF centers. We report a Pandoraea spp. outbreak comprising 24 non-CF patients at a large university hospital and a neighboring heart center in Ger...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617358/ https://www.ncbi.nlm.nih.gov/pubmed/37877517 http://dx.doi.org/10.3201/eid2911.230493 |
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author | Kruis, Tassilo Menzel, Peter Schwarzer, Rolf Wiesener, Solveigh Schoenrath, Felix Klefisch, Frank Stegemann, Miriam Pfäfflin, Frieder |
author_facet | Kruis, Tassilo Menzel, Peter Schwarzer, Rolf Wiesener, Solveigh Schoenrath, Felix Klefisch, Frank Stegemann, Miriam Pfäfflin, Frieder |
author_sort | Kruis, Tassilo |
collection | PubMed |
description | Pandoraea spp. are gram-negative, nonfermenting rods mainly known to infect patients with cystic fibrosis (CF). Outbreaks have been reported from several CF centers. We report a Pandoraea spp. outbreak comprising 24 non-CF patients at a large university hospital and a neighboring heart center in Germany during July 2019–December 2021. Common features in the patients were critical illness, invasive ventilation, antimicrobial pretreatment, and preceding surgery. Complicated and relapsing clinical courses were observed in cases with intraabdominal infections but not those with lower respiratory tract infections. Genomic analysis of 15 isolates identified Pandoraea commovens as the genetically most similar species and confirmed the clonality of the outbreak strain, designated P. commovens strain LB-19-202-79. The strain exhibited resistance to most antimicrobial drugs except ampicillin/sulbactam, imipenem, and trimethoprim/sulfamethoxazole. Our findings suggest Pandoraea spp. can spread among non-CF patients and underscore that clinicians and microbiologists should be vigilant in detecting and assessing unusual pathogens. |
format | Online Article Text |
id | pubmed-10617358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-106173582023-11-01 Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 Kruis, Tassilo Menzel, Peter Schwarzer, Rolf Wiesener, Solveigh Schoenrath, Felix Klefisch, Frank Stegemann, Miriam Pfäfflin, Frieder Emerg Infect Dis Synopsis Pandoraea spp. are gram-negative, nonfermenting rods mainly known to infect patients with cystic fibrosis (CF). Outbreaks have been reported from several CF centers. We report a Pandoraea spp. outbreak comprising 24 non-CF patients at a large university hospital and a neighboring heart center in Germany during July 2019–December 2021. Common features in the patients were critical illness, invasive ventilation, antimicrobial pretreatment, and preceding surgery. Complicated and relapsing clinical courses were observed in cases with intraabdominal infections but not those with lower respiratory tract infections. Genomic analysis of 15 isolates identified Pandoraea commovens as the genetically most similar species and confirmed the clonality of the outbreak strain, designated P. commovens strain LB-19-202-79. The strain exhibited resistance to most antimicrobial drugs except ampicillin/sulbactam, imipenem, and trimethoprim/sulfamethoxazole. Our findings suggest Pandoraea spp. can spread among non-CF patients and underscore that clinicians and microbiologists should be vigilant in detecting and assessing unusual pathogens. Centers for Disease Control and Prevention 2023-11 /pmc/articles/PMC10617358/ /pubmed/37877517 http://dx.doi.org/10.3201/eid2911.230493 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Synopsis Kruis, Tassilo Menzel, Peter Schwarzer, Rolf Wiesener, Solveigh Schoenrath, Felix Klefisch, Frank Stegemann, Miriam Pfäfflin, Frieder Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 |
title | Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 |
title_full | Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 |
title_fullStr | Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 |
title_full_unstemmed | Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 |
title_short | Outbreak of Pandoraea commovens Infections among Non–Cystic Fibrosis Intensive Care Patients, Germany, 2019–2021 |
title_sort | outbreak of pandoraea commovens infections among non–cystic fibrosis intensive care patients, germany, 2019–2021 |
topic | Synopsis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617358/ https://www.ncbi.nlm.nih.gov/pubmed/37877517 http://dx.doi.org/10.3201/eid2911.230493 |
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