Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008

We report the autopsy pathology findings of a 21-week stillborn fetus with congenital mpox syndrome that occurred in the Democratic Republic of the Congo in 2008. The fetus acquired mpox from the mother after intrauterine transplacental monkeypox virus transmission. We confirmed monkeypox virus infe...

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Autores principales: Schwartz, David A., Mbala-Kingebeni, Placide, Patterson, Kerry, Huggins, John W., Pittman, Phillip R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617360/
https://www.ncbi.nlm.nih.gov/pubmed/37705112
http://dx.doi.org/10.3201/eid2911.230606
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author Schwartz, David A.
Mbala-Kingebeni, Placide
Patterson, Kerry
Huggins, John W.
Pittman, Phillip R.
author_facet Schwartz, David A.
Mbala-Kingebeni, Placide
Patterson, Kerry
Huggins, John W.
Pittman, Phillip R.
author_sort Schwartz, David A.
collection PubMed
description We report the autopsy pathology findings of a 21-week stillborn fetus with congenital mpox syndrome that occurred in the Democratic Republic of the Congo in 2008. The fetus acquired mpox from the mother after intrauterine transplacental monkeypox virus transmission. We confirmed monkeypox virus infection in the mother, fetus, and placenta by using a monkeypox virus–specific quantitative PCR. Subtyping of the virus was not performed, but the mother and fetus were almost certainly infected with the clade I variant that was endemic in the Democratic Republic of the Congo at the time. Risk for intrauterine infection appears to differ between virus clades, but clinicians should be aware of potential for intrauterine monkeypox virus transmission among pregnant persons during ongoing and future mpox outbreaks.
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spelling pubmed-106173602023-11-01 Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008 Schwartz, David A. Mbala-Kingebeni, Placide Patterson, Kerry Huggins, John W. Pittman, Phillip R. Emerg Infect Dis Synopsis We report the autopsy pathology findings of a 21-week stillborn fetus with congenital mpox syndrome that occurred in the Democratic Republic of the Congo in 2008. The fetus acquired mpox from the mother after intrauterine transplacental monkeypox virus transmission. We confirmed monkeypox virus infection in the mother, fetus, and placenta by using a monkeypox virus–specific quantitative PCR. Subtyping of the virus was not performed, but the mother and fetus were almost certainly infected with the clade I variant that was endemic in the Democratic Republic of the Congo at the time. Risk for intrauterine infection appears to differ between virus clades, but clinicians should be aware of potential for intrauterine monkeypox virus transmission among pregnant persons during ongoing and future mpox outbreaks. Centers for Disease Control and Prevention 2023-11 /pmc/articles/PMC10617360/ /pubmed/37705112 http://dx.doi.org/10.3201/eid2911.230606 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Schwartz, David A.
Mbala-Kingebeni, Placide
Patterson, Kerry
Huggins, John W.
Pittman, Phillip R.
Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008
title Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008
title_full Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008
title_fullStr Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008
title_full_unstemmed Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008
title_short Congenital Mpox Syndrome (Clade I) in Stillborn Fetus after Placental Infection and Intrauterine Transmission, Democratic Republic of the Congo, 2008
title_sort congenital mpox syndrome (clade i) in stillborn fetus after placental infection and intrauterine transmission, democratic republic of the congo, 2008
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617360/
https://www.ncbi.nlm.nih.gov/pubmed/37705112
http://dx.doi.org/10.3201/eid2911.230606
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