Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques

INTRODUCTION: Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1‐42 (Aβ(1‐42)) or phosphorylated tau, but additional strategies are needed to reduce neuropathology at earlier stages prior to neuronal damage. Longstanding data show that calcium...

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Detalles Bibliográficos
Autores principales: Bathla, Shveta, Datta, Dibyadeep, Liang, Feng, Barthelemy, Nicolas, Wiseman, Robyn, Slusher, Barbara S, Asher, Jennifer, Zeiss, Caroline, Ekanayake‐Alper, Dil, Holden, Daniel, Terwilliger, Gordon, Duque, Alvaro, Arellano, Jon, van Dyck, Christopher, Bateman, Randall J., Xie, Zhongcong, Nairn, Angus C., Arnsten, Amy F. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617575/
https://www.ncbi.nlm.nih.gov/pubmed/37915375
http://dx.doi.org/10.1002/trc2.12431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617575/
https://www.ncbi.nlm.nih.gov/pubmed/37915375
http://dx.doi.org/10.1002/trc2.12431

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