Cargando…

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques

INTRODUCTION: Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1‐42 (Aβ(1‐42)) or phosphorylated tau, but additional strategies are needed to reduce neuropathology at earlier stages prior to neuronal damage. Longstanding data show that calcium...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bathla, Shveta, Datta, Dibyadeep, Liang, Feng, Barthelemy, Nicolas, Wiseman, Robyn, Slusher, Barbara S, Asher, Jennifer, Zeiss, Caroline, Ekanayake‐Alper, Dil, Holden, Daniel, Terwilliger, Gordon, Duque, Alvaro, Arellano, Jon, van Dyck, Christopher, Bateman, Randall J., Xie, Zhongcong, Nairn, Angus C., Arnsten, Amy F. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617575/ https://www.ncbi.nlm.nih.gov/pubmed/37915375 http://dx.doi.org/10.1002/trc2.12431

Ejemplares similares

Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders
por: Yang, Shengtao, et al.
Publicado: (2022)

Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
por: Knedlík, Tomáš, et al.
Publicado: (2017)

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance
por: Datta, Dibyadeep, et al.
Publicado: (2021)

Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long‐term benefits in mice with traumatic brain injury
por: Ji, Tongjie, et al.
Publicado: (2023)

The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex
por: Arnsten, Amy F. T., et al.
Publicado: (2020)

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
por: Datta, Dibyadeep, et al.
Publicado: (2020)

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis
por: Hollinger, Kristen R., et al.
Publicado: (2022)

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau
por: Leslie, Shannon N., et al.
Publicado: (2020)

Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates
por: Leslie, Shannon N., et al.
Publicado: (2021)

Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits
por: Datta, Dibyadeep, et al.
Publicado: (2020)

Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates
por: Datta, Dibyadeep, et al.
Publicado: (2021)

Deciphering Spatial Protein–Protein Interactions in Brain Using Proximity Labeling
por: Mathew, Boby, et al.
Publicado: (2022)

CARBOXYPEPTIDASE : III. THE ESTIMATION OF CARBOXYPEPTIDASE AND PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II
por: Gori, Sadakatali S., et al.
Publicado: (2022)

CARBOXYPEPTIDASE : I. THE PREPARATION OF CRYSTALLINE CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Loss of Prefrontal Cortical Higher Cognition with Uncontrollable Stress: Molecular Mechanisms, Changes with Age, and Relevance to Treatment
por: Datta, Dibyadeep, et al.
Publicado: (2019)

Glutamate Carboxypeptidase II Inhibition Behaviorally and Physiologically Improves Pyridoxine-Induced Neuropathy in Rats
por: Potter, Michelle C., et al.
Publicado: (2014)

CARBOXYPEPTIDASE : II. THE PARTIAL PURIFICATION OF PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA
por: Nonaka, Takahiro, et al.
Publicado: (2017)

Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
por: Woo, Elizabeth, et al.
Publicado: (2022)

Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies
por: Rojas, Camilo, et al.
Publicado: (2011)

Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective
por: Arnsten, Amy F. T., et al.
Publicado: (2021)

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
por: Arnsten, Amy F. T., et al.
Publicado: (2020)

Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes
por: Woo, Elizabeth, et al.
Publicado: (2021)

Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex
por: Yang, Sheng-Tao, et al.
Publicado: (2018)

Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders
por: Arnsten, Amy F. T., et al.
Publicado: (2023)

Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy
por: Sah, Nirnath, et al.
Publicado: (2023)

Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance
por: Yang, Sheng-Tao, et al.
Publicado: (2020)

Measurement of carboxypeptidase R by colorimetric assay
por: Komura, H, et al.
Publicado: (2002)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

Memorandum: I217 update
por: CERN. Geneva. SPS-PS Experiments Committee
Publicado: (1999)

Health Tract, No. 217: Hunger
Publicado: (1865)

Health Tract, No. 217: Hunger
Publicado: (1864)

Clinics in diagnostic imaging (217)
por: Ong, Wu Lin Low, et al.
Publicado: (2023)

Regulation of dopamine transporter activity by carboxypeptidase E
por: Zhang, Heping, et al.
Publicado: (2009)

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes
por: Jedlickova, Lucie, et al.
Publicado: (2022)

HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
por: Moon, Yunwon, et al.
Publicado: (2020)

Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels
por: Wennström, Malin, et al.
Publicado: (2022)

Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury
por: Cabeza, O. Arteaga, et al.
Publicado: (2020)

Architecture of the Entorhinal Cortex A Review of Entorhinal Anatomy in Rodents with Some Comparative Notes
por: Witter, Menno P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8eb2c6uqmdoneonmasu6kmhuca