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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Cells use ubiquitin to mark proteins for proteasomal degradation. While the proteasome also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is unclear. Here we found that midnolin promoted the destruction of many nuclear proteins including transcription factors encode...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617673/ https://www.ncbi.nlm.nih.gov/pubmed/37616343 http://dx.doi.org/10.1126/science.adh5021 |