PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models

Unabated activation of the NLR family pyrin domain–containing 3 (NLRP3) inflammasome is linked with the pathogenesis of various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both pharmacological and genetic approaches, we demonstrate t...

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Detalles Bibliográficos
Autores principales: Baldrighi, Marta, Doreth, Christian, Li, Yang, Zhao, Xiaohui, Warner, Emily, Chenoweth, Hannah, Kishore, Kamal, Umrania, Yagnesh, Minde, David-Paul, Thome, Sarah, Yu, Xian, Lu, Yuning, Knapton, Alice, Harrison, James, Clarke, Murray, Latz, Eicke, de Cárcer, Guillermo, Malumbres, Marcos, Ryffel, Bernhard, Bryant, Clare, Liu, Jinping, Lilley, Kathryn S., Mallat, Ziad, Li, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617773/
https://www.ncbi.nlm.nih.gov/pubmed/37698938
http://dx.doi.org/10.1172/JCI162129

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