Cargando…

Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance

The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in development of chronic inflammatory disorders and the inflamed tumor microenvironment (TME) associated with most solid tumors. We examined whether loss of TREM1 signaling can abrogate the immunosuppressive TME and e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ajith, Ashwin, Mamouni, Kenza, Horuzsko, Daniel D., Musa, Abu, Dzutsev, Amiran K., Fang, Jennifer R., Chadli, Ahmed, Zhu, Xingguo, Lebedyeva, Iryna, Trinchieri, Giorgio, Horuzsko, Anatolij
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617775/ https://www.ncbi.nlm.nih.gov/pubmed/37651197 http://dx.doi.org/10.1172/JCI167951

Ejemplares similares

Humanized Mouse Model as a Novel Approach in the Assessment of Human Allogeneic Responses in Organ Transplantation
por: Ajith, Ashwin, et al.
Publicado: (2021)

HLA-G Dimers in the Prolongation of Kidney Allograft Survival
por: Ezeakile, Maureen, et al.
Publicado: (2014)

Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
por: Patwardhan, Chaitanya A., et al.
Publicado: (2023)

Mice with endothelial cell‐selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction
por: Buncha, Vadym, et al.
Publicado: (2023)

Tolerogenic Function of Dimeric Forms of HLA-G Recombinant Proteins: A Comparative Study In Vivo
por: Favier, Benoit, et al.
Publicado: (2011)

Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques
por: Sui, Yongjun, et al.
Publicado: (2018)

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
por: Pan, Dong, et al.
Publicado: (2022)

Function of TREM1 and TREM2 in Liver-Related Diseases
por: Sun, Huifang, et al.
Publicado: (2020)

sTREM-1 is a specific biomarker of TREM-1 pathway activation
por: Jolly, Lucie, et al.
Publicado: (2021)

Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy
por: Namasivayam, Sivaranjani, et al.
Publicado: (2017)

Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia
por: Moslehi, Roxana, et al.
Publicado: (2014)

Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
por: Ren, Yijie, et al.
Publicado: (2022)

ACKR4 restrains antitumor immunity by regulating CCL21
por: Whyte, Carly E., et al.
Publicado: (2020)

Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels
por: Feng, Jia-Yih, et al.
Publicado: (2018)

Early transcriptome changes associated with western diet induced NASH in Ldlr(−/−) mice points to activation of hepatic macrophages and an acute phase response
por: Padiadpu, Jyothi, et al.
Publicado: (2023)

TREM-1, TREM-2 and their association with disease severity in patients with COVID-19
por: Fan, Ruyue, et al.
Publicado: (2023)

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma
por: Sun, Rui, et al.
Publicado: (2023)

Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma
por: Ford, Jill W., et al.
Publicado: (2022)

TREM2 Acts as a Tumor Suppressor in Colorectal Carcinoma through Wnt1/β-catenin and Erk Signaling
por: Kim, Su-Man, et al.
Publicado: (2019)

Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis
por: Chen, Keqiang, et al.
Publicado: (2021)

TREM-1 promotes intestinal tumorigenesis
por: Saurer, Leslie, et al.
Publicado: (2017)

TREM-1 Modulation Strategies for Sepsis
por: Siskind, Sara, et al.
Publicado: (2022)

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

Transkingdom Network Analysis (TkNA): a systems framework for inferring causal factors underlying host-microbiota and other multi-omic interactions
por: Newman, Nolan K., et al.
Publicado: (2023)

Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia
por: Moslehi, Roxana, et al.
Publicado: (2013)

Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer
por: Moslehi, Roxana, et al.
Publicado: (2020)

Expression of Concern: ACKR4 restrains antitumor immunity by regulating CCL21
Publicado: (2023)

Crystal structure of ethyl 2-methyl-5,10-dioxo-4-phenyl-5,10-dihydro-4H-11-thia-1,4a-diazabenzo[b]fluorene-3-carboxylate
por: Yartsev, Yegor, et al.
Publicado: (2018)

Ethyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
por: Zubatyuk, Roman I., et al.
Publicado: (2010)

Correction: Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid‐soluble TREM2
por: Wang, Zuo‐Teng, et al.
Publicado: (2023)

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells
por: Liu, Feiyan, et al.
Publicado: (2016)

Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics
por: Phan, Trinh T. T., et al.
Publicado: (2022)

The ratio of urinary TREM-1/TREM-2 mRNA expression in chronic kidney disease and renal fibrosis
por: Cao, Yuhan, et al.
Publicado: (2021)

TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin
por: Aldasoro Arguinano, Alex-Ander, et al.
Publicado: (2017)

Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer
por: Srivastava, Minu K, et al.
Publicado: (2012)

Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis
por: Padiadpu, Jyothi, et al.
Publicado: (2023)

TREM-1 levels are elevated in patients with liver cirrhosis
por: Gurney, SD, et al.
Publicado: (2013)

TREM-1 as a Potential Therapeutic Target in Psoriasis
por: Hyder, Luke A., et al.
Publicado: (2013)

Data on TREM-1 activation destabilizing carotid plaques
por: Rao, Velidi H., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_481nf6v0g5ci74fla4qgtbo83i