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Tolerability and Efficacy of the Anticluster of Differentiation 47 Antibody Magrolimab Combined With Azacitidine in Patients With Previously Untreated AML: Phase Ib Results
PURPOSE: Magrolimab is a first-in-class humanized monoclonal antibody against cluster of differentiation 47, an antiphagocytic signal used by cancer cells to evade phagocytosis. Azacitidine upregulates prophagocytic signals on AML cells, further increasing phagocytosis when combined with magrolimab....
Autores principales: | Daver, Naval G., Vyas, Paresh, Kambhampati, Suman, Al Malki, Monzr M., Larson, Richard A., Asch, Adam S., Mannis, Gabriel, Chai-Ho, Wanxing, Tanaka, Tiffany N., Bradley, Terrence J., Jeyakumar, Deepa, Wang, Eunice S., Sweet, Kendra, Kantarjian, Hagop M., Garcia-Manero, Guillermo, Komrokji, Rami, Xing, Guan, Ramsingh, Giridharan, Renard, Camille, Zeidner, Joshua F., Sallman, David A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617926/ https://www.ncbi.nlm.nih.gov/pubmed/37703506 http://dx.doi.org/10.1200/JCO.22.02604 |
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