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A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the rev...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618084/ https://www.ncbi.nlm.nih.gov/pubmed/37322065 http://dx.doi.org/10.1038/s41380-023-02095-y |
| _version_ | 1785129700391124992 |
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| author | Jauhar, Sameer Arnone, Danilo Baldwin, David S. Bloomfield, Michael Browning, Michael Cleare, Anthony J. Corlett, Phillip Deakin, J. F. William Erritzoe, David Fu, Cynthia Fusar-Poli, Paolo Goodwin, Guy M. Hayes, Joseph Howard, Robert Howes, Oliver D. Juruena, Mario F. Lam, Raymond W. Lawrie, Stephen M. McAllister-Williams, Hamish Marwaha, Steven Matuskey, David McCutcheon, Robert A. Nutt, David J. Pariante, Carmine Pillinger, Toby Radhakrishnan, Rajiv Rucker, James Selvaraj, Sudhakar Stokes, Paul Upthegrove, Rachel Yalin, Nefize Yatham, Lakshmi Young, Allan H. Zahn, Roland Cowen, Philip J. |
| author_facet | Jauhar, Sameer Arnone, Danilo Baldwin, David S. Bloomfield, Michael Browning, Michael Cleare, Anthony J. Corlett, Phillip Deakin, J. F. William Erritzoe, David Fu, Cynthia Fusar-Poli, Paolo Goodwin, Guy M. Hayes, Joseph Howard, Robert Howes, Oliver D. Juruena, Mario F. Lam, Raymond W. Lawrie, Stephen M. McAllister-Williams, Hamish Marwaha, Steven Matuskey, David McCutcheon, Robert A. Nutt, David J. Pariante, Carmine Pillinger, Toby Radhakrishnan, Rajiv Rucker, James Selvaraj, Sudhakar Stokes, Paul Upthegrove, Rachel Yalin, Nefize Yatham, Lakshmi Young, Allan H. Zahn, Roland Cowen, Philip J. |
| author_sort | Jauhar, Sameer |
| collection | PubMed |
| description | A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this. |
| format | Online Article Text |
| id | pubmed-10618084 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106180842023-11-02 A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression Jauhar, Sameer Arnone, Danilo Baldwin, David S. Bloomfield, Michael Browning, Michael Cleare, Anthony J. Corlett, Phillip Deakin, J. F. William Erritzoe, David Fu, Cynthia Fusar-Poli, Paolo Goodwin, Guy M. Hayes, Joseph Howard, Robert Howes, Oliver D. Juruena, Mario F. Lam, Raymond W. Lawrie, Stephen M. McAllister-Williams, Hamish Marwaha, Steven Matuskey, David McCutcheon, Robert A. Nutt, David J. Pariante, Carmine Pillinger, Toby Radhakrishnan, Rajiv Rucker, James Selvaraj, Sudhakar Stokes, Paul Upthegrove, Rachel Yalin, Nefize Yatham, Lakshmi Young, Allan H. Zahn, Roland Cowen, Philip J. Mol Psychiatry Comment A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this. Nature Publishing Group UK 2023-06-16 2023 /pmc/articles/PMC10618084/ /pubmed/37322065 http://dx.doi.org/10.1038/s41380-023-02095-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Comment Jauhar, Sameer Arnone, Danilo Baldwin, David S. Bloomfield, Michael Browning, Michael Cleare, Anthony J. Corlett, Phillip Deakin, J. F. William Erritzoe, David Fu, Cynthia Fusar-Poli, Paolo Goodwin, Guy M. Hayes, Joseph Howard, Robert Howes, Oliver D. Juruena, Mario F. Lam, Raymond W. Lawrie, Stephen M. McAllister-Williams, Hamish Marwaha, Steven Matuskey, David McCutcheon, Robert A. Nutt, David J. Pariante, Carmine Pillinger, Toby Radhakrishnan, Rajiv Rucker, James Selvaraj, Sudhakar Stokes, Paul Upthegrove, Rachel Yalin, Nefize Yatham, Lakshmi Young, Allan H. Zahn, Roland Cowen, Philip J. A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| title | A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| title_full | A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| title_fullStr | A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| title_full_unstemmed | A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| title_short | A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| title_sort | leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression |
| topic | Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618084/ https://www.ncbi.nlm.nih.gov/pubmed/37322065 http://dx.doi.org/10.1038/s41380-023-02095-y |
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