Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism

Histone acetylation involves the transfer of two-carbon units to the nucleus that are embedded in low-concentration metabolites. We found that lactate, a high-concentration metabolic byproduct, can be a major carbon source for histone acetylation through oxidation-dependent metabolism. Both in cells...

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Detalles Bibliográficos
Autores principales: An, Yong Jin, Jo, Sihyang, Kim, Jin-Mo, Kim, Han Sun, Kim, Hyun Young, Jeon, Sang-Min, Han, Dawool, Yook, Jong In, Kang, Keon Wook, Park, Sunghyouk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618192/
https://www.ncbi.nlm.nih.gov/pubmed/37779146
http://dx.doi.org/10.1038/s12276-023-01095-w

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