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Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells

Ex vivo gene therapy (GT) is a promising treatment for inherited genetic diseases. An ideal transduction protocol should determine high gene marking in long-term self-renewing hematopoietic stem cells (HSCs), preserving their repopulation potential during in vitro manipulation. In the context of the...

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Detalles Bibliográficos
Autores principales:	Poletti, Valentina, Montepeloso, Annita, Pellin, Danilo, Biffi, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618226/ https://www.ncbi.nlm.nih.gov/pubmed/37920236 http://dx.doi.org/10.1016/j.omtm.2023.101131

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