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Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice

Metastatic hepatocellular carcinoma (HCC) is the most lethal malignancy and lacks effective treatment. FBXL6 is overexpressed in human hepatocellular carcinoma (HCC), but whether this change drives liver tumorigenesis and lung metastasis in vivo remains unknown. In this study, we aimed to identify F...

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Detalles Bibliográficos
Autores principales:	Zhang, Jie, Lin, Xiao-Tong, Yu, Hong-Qiang, Fang, Lei, Wu, Di, Luo, Yuan-Deng, Zhang, Yu-Jun, Xie, Chuan-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618235/ https://www.ncbi.nlm.nih.gov/pubmed/37653031 http://dx.doi.org/10.1038/s12276-023-01060-7

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