Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is cru...

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Autores principales: Lee, Yeji, Jeong, Michaela, Park, Jeongeun, Jung, Hyein, Lee, Hyukjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618257/
https://www.ncbi.nlm.nih.gov/pubmed/37779140
http://dx.doi.org/10.1038/s12276-023-01086-x
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author Lee, Yeji
Jeong, Michaela
Park, Jeongeun
Jung, Hyein
Lee, Hyukjin
author_facet Lee, Yeji
Jeong, Michaela
Park, Jeongeun
Jung, Hyein
Lee, Hyukjin
author_sort Lee, Yeji
collection PubMed
description Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles.
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spelling pubmed-106182572023-11-02 Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics Lee, Yeji Jeong, Michaela Park, Jeongeun Jung, Hyein Lee, Hyukjin Exp Mol Med Review Article Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles. Nature Publishing Group UK 2023-10-02 /pmc/articles/PMC10618257/ /pubmed/37779140 http://dx.doi.org/10.1038/s12276-023-01086-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Lee, Yeji
Jeong, Michaela
Park, Jeongeun
Jung, Hyein
Lee, Hyukjin
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
title Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
title_full Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
title_fullStr Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
title_full_unstemmed Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
title_short Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
title_sort immunogenicity of lipid nanoparticles and its impact on the efficacy of mrna vaccines and therapeutics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618257/
https://www.ncbi.nlm.nih.gov/pubmed/37779140
http://dx.doi.org/10.1038/s12276-023-01086-x
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