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Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer

Kirsten rat sarcoma viral oncogene homologue (KRAS) is a frequent oncogenic driver of solid tumors, including non-small cell lung cancer (NSCLC). The treatment and outcomes of KRAS-mutant cancers have not been dramatically revolutionized by direct KRAS-targeted therapies because of the lack of deep...

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Detalles Bibliográficos
Autores principales:	Shin, Dong Hoon, Jo, Jeong Yeon, Choi, Minyoung, Kim, Kyung-Hee, Bae, Young-Ki, Kim, Sang Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618295/ https://www.ncbi.nlm.nih.gov/pubmed/37779142 http://dx.doi.org/10.1038/s12276-023-01091-0

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