Cargando…

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease

In this study, we have employed metabolomics technology in combination with network pharmacology to ascertain the key metabolites and hub genes. The objective was to explore the pathway of Qibai Pingfei Capsule (QBPF) in treating COPD through metabolomics. We identified 96 differential metabolites i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Jinghui, Liu, Mengxiang, Gao, Yating, Liu, Changan, Wu, Fan, Tong, Jiabing, Li, Zegeng, Zhu, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618342/ https://www.ncbi.nlm.nih.gov/pubmed/37920214 http://dx.doi.org/10.3389/fphar.2023.1258138

Ejemplares similares

The treatment of Qibai Pingfei Capsule on chronic obstructive pulmonary disease may be mediated by Th17/Treg balance and gut-lung axis microbiota
por: Jia, Yu, et al.
Publicado: (2022)

Targeting non-coding RNA H19: A potential therapeutic approach in pulmonary diseases
por: Xie, Jinghui, et al.
Publicado: (2022)

The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease
por: Hu, Yuedi, et al.
Publicado: (2021)

The Pharmacological Mechanism of Guchangzhixie Capsule Against Experimental Colitis
por: Yan, Jing, et al.
Publicado: (2021)

Deciphering the Pharmacological Mechanisms of Guizhi-Fuling Capsule on Primary Dysmenorrhea Through Network Pharmacology
por: Zhang, Siqin, et al.
Publicado: (2021)

Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis
por: Liu, Tong, et al.
Publicado: (2023)

Metabolomics Study of Guizhi Fuling Capsules in Rats With Cold Coagulation Dysmenorrhea
por: Zhang, Yu, et al.
Publicado: (2021)

Interpreting the Pharmacological Mechanisms of Huachansu Capsules on Hepatocellular Carcinoma Through Combining Network Pharmacology and Experimental Evaluation
por: Huang, Jihan, et al.
Publicado: (2020)

Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy
por: Zhang, Jinying, et al.
Publicado: (2023)

Identification of kaempferol as an OSX upregulator by network pharmacology-based analysis of qianggu Capsule for osteoporosis
por: Huang, Ann Yehong, et al.
Publicado: (2022)

Investigating the effects of Liushen Capsules (LS) on the metabolome of seasonal influenza: A randomized clinical trial
por: Ma, Qinhai, et al.
Publicado: (2022)

Study of the Mechanism of Action of Guanxin Shutong Capsules in the Treatment of Coronary Heart Disease Based on Metabolomics
por: Wang, Dan, et al.
Publicado: (2021)

Corrigendum: Investigating the effects of Liushen Capsules (LS) on the metabolome of seasonal influenza: A randomized clinical trial
por: Ma, Qinhai, et al.
Publicado: (2023)

Pharmacological effects of Bufei Jianpi granule on chronic obstructive pulmonary disease and its metabolism in rats
por: Yang, Xin-Xin, et al.
Publicado: (2022)

Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model: In Vitro Pharmacology and Cell Metabolomics
por: Yin, Fengxia, et al.
Publicado: (2022)

Integrated Metabolomics and Network Pharmacology Analysis Immunomodulatory Mechanisms of Qifenggubiao Granules
por: Guo, Bindan, et al.
Publicado: (2022)

Roles of autophagy-related genes in the therapeutic effects of Xuanfei Pingchuan capsules on chronic obstructive pulmonary disease based on transcriptome sequencing analysis
por: Zhang, Ye, et al.
Publicado: (2023)

Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion
por: Tong, Xiyang, et al.
Publicado: (2019)

Screening for Anti-Inflammation Quality Markers of Lianhua Qingwen Capsule Based on Network Pharmacology, UPLC, and Biological Activity
por: Zhou, Yongfeng, et al.
Publicado: (2021)

EPHX1 and GSTP1 polymorphisms are associated with COPD risk: a systematic review and meta-analysis
por: Yang, Qinjun, et al.
Publicado: (2023)

The clinical characteristics and treatment response of patients with chronic obstructive pulmonary disease with low body mass index
por: Song, Qing, et al.
Publicado: (2023)

Anxiolytic effect of YangshenDingzhi granules: Integrated network pharmacology and hippocampal metabolomics
por: Lv, Shimeng, et al.
Publicado: (2022)

Integrating Strategies of Herbal Metabolomics, Network Pharmacology, and Experiment Validation to Investigate Frankincense Processing Effects
por: Ning, Zhangchi, et al.
Publicado: (2018)

Integrated Plasma and Bile Metabolomics Based on an UHPLC-Q/TOF-MS and Network Pharmacology Approach to Explore the Potential Mechanism of Schisandra chinensis-Protection From Acute Alcoholic Liver Injury
por: Su, Lianlin, et al.
Publicado: (2020)

Metabolomics Analysis Coupled With UPLC/MS on Therapeutic Effect of Jigucao Capsule Against Dampness-Heat Jaundice Syndrome
por: He, Yanmei, et al.
Publicado: (2022)

Metabolomics analysis delineates the therapeutic effects of Yinlan Tiaozhi capsule on triton WR-1339 -induced hyperlipidemia in mice
por: Xiao, Guanlin, et al.
Publicado: (2023)

Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology
por: Chen, Lisheng, et al.
Publicado: (2021)

Network Pharmacology and Experimental Assessment to Explore the Pharmacological Mechanism of Qimai Feiluoping Decoction Against Pulmonary Fibrosis
por: Yang, Yingying, et al.
Publicado: (2021)

Investigation of the Multi-Target Mechanism of Guanxin-Shutong Capsule in Cerebrovascular Diseases: A Systems Pharmacology and Experimental Assessment
por: Zhang, Juanli, et al.
Publicado: (2021)

Exploration of the Modulatory Property Mechanism of ELeng Capsule in the Treatment of Endometriosis Using Transcriptomics Combined With Systems Network Pharmacology
por: Zheng, Weilin, et al.
Publicado: (2021)

Zhilong Huoxue Tongyu Capsules' Effects on ischemic stroke: An assessment using fecal 16S rRNA gene sequencing and untargeted serum metabolomics
por: Wang, Raoqiong, et al.
Publicado: (2022)

Naoxin’an capsules protect brain function and structure in patients with vascular cognitive impairment
por: Lu, Hui, et al.
Publicado: (2023)

Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology
por: Luo, Wen, et al.
Publicado: (2021)

Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics
por: Shang, Xiaofei, et al.
Publicado: (2022)

The Interventional Effects of Tubson-2 Decoction on Ovariectomized Rats as Determined by a Combination of Network Pharmacology and Metabolomics
por: Yang, Fan, et al.
Publicado: (2020)

Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma
por: Wang, Yajuan, et al.
Publicado: (2022)

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Action of Huang Qin Decoction for Treament of Diabetic Liver Injury
por: Xu, Xiaomin, et al.
Publicado: (2022)

Rubus chingii Hu: A Review of the Phytochemistry and Pharmacology
por: Yu, Guohua, et al.
Publicado: (2019)

Practical Protocol for Comprehensively Evaluating Sulfur-Fumigation of Baizhi Based on Metabolomics, Pharmacology, and Cytotoxicity
por: Deng, Ai-Ping, et al.
Publicado: (2022)

Investigation into the potential mechanism and molecular targets of Fufang Xueshuantong capsule for the treatment of ischemic stroke based on network pharmacology and molecular docking
por: Wang, Lei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gpt5cnr49rlj8qpqbs7mede45o