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Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment

A class of exceptionally bioactive molecules known as reactive oxygen species (ROS) have been widely studied in the context of cancer. They play a significant role in the etiopathogenesis for cancer. Implication of ROS in cancer biology is an evolving area, considering the recent advances; insights...

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Autores principales: Verma, Priyanka, Rishi, Bhavika, George, Noreen Grace, Kushwaha, Neetu, Dhandha, Himanshu, Kaur, Manpreet, Jain, Ankur, Jain, Aditi, Chaudhry, Sumita, Singh, Amitabh, Siraj, Fouzia, Misra, Aroonima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618351/
https://www.ncbi.nlm.nih.gov/pubmed/37920248
http://dx.doi.org/10.3389/pore.2023.1611415
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author Verma, Priyanka
Rishi, Bhavika
George, Noreen Grace
Kushwaha, Neetu
Dhandha, Himanshu
Kaur, Manpreet
Jain, Ankur
Jain, Aditi
Chaudhry, Sumita
Singh, Amitabh
Siraj, Fouzia
Misra, Aroonima
author_facet Verma, Priyanka
Rishi, Bhavika
George, Noreen Grace
Kushwaha, Neetu
Dhandha, Himanshu
Kaur, Manpreet
Jain, Ankur
Jain, Aditi
Chaudhry, Sumita
Singh, Amitabh
Siraj, Fouzia
Misra, Aroonima
author_sort Verma, Priyanka
collection PubMed
description A class of exceptionally bioactive molecules known as reactive oxygen species (ROS) have been widely studied in the context of cancer. They play a significant role in the etiopathogenesis for cancer. Implication of ROS in cancer biology is an evolving area, considering the recent advances; insights into their generation, role of genomic and epigenetic regulators for ROS, earlier thought to be a chemical process, with interrelations with cell death pathways- Apoptosis, ferroptosis, necroptosis and autophagy has been explored for newer targets that shift the balance of ROS towards cancer cell death. ROS are signal transducers that induce angiogenesis, invasion, cell migration, and proliferation at low to moderate concentrations and are considered normal by-products of a range of biological activities. Although ROS is known to exist in the oncology domain since time immemorial, its excessive quantities are known to damage organelles, membranes, lipids, proteins, and nucleic acids, resulting in cell death. In the last two decades, numerous studies have demonstrated immunotherapies and other anticancer treatments that modulate ROS levels have promising in vitro and in vivo effects. This review also explores recent targets for therapeutic interventions in cancer that are based on ROS generation or inhibition to disrupt the cell oxidative stress balance. Examples include-metabolic targets, targeted therapy with biomarkers, natural extracts and nutraceuticals and targets developed in the area of nano medicine. In this review, we present the molecular pathways which can be used to create therapy plans that target cancer by regulating ROS levels, particularly current developments and potential prospects for the effective implementation of ROS-mediated therapies in clinical settings. The recent advances in complex interaction with apoptosis especially ferroptosis and its role in epigenomics and modifications are a new paradigm, to just mechanical action of ROS, as highlighted in this review. Their inhibition by nutraceuticals and natural extracts has been a scientific challenging avenue that is explored. Also, the inhibition of generation of ROS by inhibitors, immune modulators and inhibitors of apoptosis and ferroptosis is explored in this review.
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spelling pubmed-106183512023-11-02 Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment Verma, Priyanka Rishi, Bhavika George, Noreen Grace Kushwaha, Neetu Dhandha, Himanshu Kaur, Manpreet Jain, Ankur Jain, Aditi Chaudhry, Sumita Singh, Amitabh Siraj, Fouzia Misra, Aroonima Pathol Oncol Res Pathology and Oncology Archive A class of exceptionally bioactive molecules known as reactive oxygen species (ROS) have been widely studied in the context of cancer. They play a significant role in the etiopathogenesis for cancer. Implication of ROS in cancer biology is an evolving area, considering the recent advances; insights into their generation, role of genomic and epigenetic regulators for ROS, earlier thought to be a chemical process, with interrelations with cell death pathways- Apoptosis, ferroptosis, necroptosis and autophagy has been explored for newer targets that shift the balance of ROS towards cancer cell death. ROS are signal transducers that induce angiogenesis, invasion, cell migration, and proliferation at low to moderate concentrations and are considered normal by-products of a range of biological activities. Although ROS is known to exist in the oncology domain since time immemorial, its excessive quantities are known to damage organelles, membranes, lipids, proteins, and nucleic acids, resulting in cell death. In the last two decades, numerous studies have demonstrated immunotherapies and other anticancer treatments that modulate ROS levels have promising in vitro and in vivo effects. This review also explores recent targets for therapeutic interventions in cancer that are based on ROS generation or inhibition to disrupt the cell oxidative stress balance. Examples include-metabolic targets, targeted therapy with biomarkers, natural extracts and nutraceuticals and targets developed in the area of nano medicine. In this review, we present the molecular pathways which can be used to create therapy plans that target cancer by regulating ROS levels, particularly current developments and potential prospects for the effective implementation of ROS-mediated therapies in clinical settings. The recent advances in complex interaction with apoptosis especially ferroptosis and its role in epigenomics and modifications are a new paradigm, to just mechanical action of ROS, as highlighted in this review. Their inhibition by nutraceuticals and natural extracts has been a scientific challenging avenue that is explored. Also, the inhibition of generation of ROS by inhibitors, immune modulators and inhibitors of apoptosis and ferroptosis is explored in this review. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10618351/ /pubmed/37920248 http://dx.doi.org/10.3389/pore.2023.1611415 Text en Copyright © 2023 Verma, Rishi, George, Kushwaha, Dhandha, Kaur, Jain, Jain, Chaudhry, Singh, Siraj and Misra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Verma, Priyanka
Rishi, Bhavika
George, Noreen Grace
Kushwaha, Neetu
Dhandha, Himanshu
Kaur, Manpreet
Jain, Ankur
Jain, Aditi
Chaudhry, Sumita
Singh, Amitabh
Siraj, Fouzia
Misra, Aroonima
Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
title Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
title_full Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
title_fullStr Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
title_full_unstemmed Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
title_short Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
title_sort recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618351/
https://www.ncbi.nlm.nih.gov/pubmed/37920248
http://dx.doi.org/10.3389/pore.2023.1611415
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