A review on the role of HAND2-AS1 in cancer

HAND2 antisense RNA 1 (HAND2-AS1) is a newly recognized lncRNA encoded by a gene on 4q34.1. This lncRNA has 10 exons and is predicted to have a positive effect on expression of certain genes. HAND2-AS1 is mainly considered as a tumor suppressive lncRNA in different tissues. Moreover, HAND2-AS1 has b...

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Autores principales: Ghafouri-Fard, Soudeh, Hussen, Bashdar Mahmud, Abdullah, Snur Rasool, Dadyar, Maryam, Taheri, Mohammad, Kiani, Arda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618356/
https://www.ncbi.nlm.nih.gov/pubmed/37204522
http://dx.doi.org/10.1007/s10238-023-01092-3
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author Ghafouri-Fard, Soudeh
Hussen, Bashdar Mahmud
Abdullah, Snur Rasool
Dadyar, Maryam
Taheri, Mohammad
Kiani, Arda
author_facet Ghafouri-Fard, Soudeh
Hussen, Bashdar Mahmud
Abdullah, Snur Rasool
Dadyar, Maryam
Taheri, Mohammad
Kiani, Arda
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description HAND2 antisense RNA 1 (HAND2-AS1) is a newly recognized lncRNA encoded by a gene on 4q34.1. This lncRNA has 10 exons and is predicted to have a positive effect on expression of certain genes. HAND2-AS1 is mainly considered as a tumor suppressive lncRNA in different tissues. Moreover, HAND2-AS1 has been shown to regulate expression of several targets with possible roles in the carcinogenesis through serving as a sponge for miRNAs. This lncRNA can also influence activity of BMP, TGF-β1, JAK/STAT and PI3K/Akt pathways. Down-regulation of HAND2-AS1 in tumor tissues has been associated with larger tumor size, higher tumor grade, higher chance of metastasis and poor clinical outcome. The present study aims at summarization of the impact of HAND2-AS1 in the carcinogenesis and its potential in cancer diagnosis or prediction of cancer prognosis.
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spelling pubmed-106183562023-11-02 A review on the role of HAND2-AS1 in cancer Ghafouri-Fard, Soudeh Hussen, Bashdar Mahmud Abdullah, Snur Rasool Dadyar, Maryam Taheri, Mohammad Kiani, Arda Clin Exp Med Review HAND2 antisense RNA 1 (HAND2-AS1) is a newly recognized lncRNA encoded by a gene on 4q34.1. This lncRNA has 10 exons and is predicted to have a positive effect on expression of certain genes. HAND2-AS1 is mainly considered as a tumor suppressive lncRNA in different tissues. Moreover, HAND2-AS1 has been shown to regulate expression of several targets with possible roles in the carcinogenesis through serving as a sponge for miRNAs. This lncRNA can also influence activity of BMP, TGF-β1, JAK/STAT and PI3K/Akt pathways. Down-regulation of HAND2-AS1 in tumor tissues has been associated with larger tumor size, higher tumor grade, higher chance of metastasis and poor clinical outcome. The present study aims at summarization of the impact of HAND2-AS1 in the carcinogenesis and its potential in cancer diagnosis or prediction of cancer prognosis. Springer International Publishing 2023-05-19 2023 /pmc/articles/PMC10618356/ /pubmed/37204522 http://dx.doi.org/10.1007/s10238-023-01092-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ghafouri-Fard, Soudeh
Hussen, Bashdar Mahmud
Abdullah, Snur Rasool
Dadyar, Maryam
Taheri, Mohammad
Kiani, Arda
A review on the role of HAND2-AS1 in cancer
title A review on the role of HAND2-AS1 in cancer
title_full A review on the role of HAND2-AS1 in cancer
title_fullStr A review on the role of HAND2-AS1 in cancer
title_full_unstemmed A review on the role of HAND2-AS1 in cancer
title_short A review on the role of HAND2-AS1 in cancer
title_sort review on the role of hand2-as1 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618356/
https://www.ncbi.nlm.nih.gov/pubmed/37204522
http://dx.doi.org/10.1007/s10238-023-01092-3
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