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Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications
This review provides an in-depth exploration of the mechanisms and applications of transcutaneous auricular vagus nerve stimulation (taVNS) in treating disorders of consciousness (DOC). Beginning with an exploration of the vagus nerve’s role in modulating brain function and consciousness, we then de...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618368/ https://www.ncbi.nlm.nih.gov/pubmed/37920298 http://dx.doi.org/10.3389/fnins.2023.1286267 |
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author | Wang, Likai Gao, Fei Wang, Zhan Liang, Feng Dai, Yongli Wang, Mengchun Wu, Jingyi Chen, Yaning Yan, Qinjie Wang, Litong |
author_facet | Wang, Likai Gao, Fei Wang, Zhan Liang, Feng Dai, Yongli Wang, Mengchun Wu, Jingyi Chen, Yaning Yan, Qinjie Wang, Litong |
author_sort | Wang, Likai |
collection | PubMed |
description | This review provides an in-depth exploration of the mechanisms and applications of transcutaneous auricular vagus nerve stimulation (taVNS) in treating disorders of consciousness (DOC). Beginning with an exploration of the vagus nerve’s role in modulating brain function and consciousness, we then delve into the neuroprotective potential of taVNS demonstrated in animal models. The subsequent sections assess the therapeutic impact of taVNS on human DOC, discussing the safety, tolerability, and various factors influencing the treatment response. Finally, the review identifies the current challenges in taVNS research and outlines future directions, emphasizing the need for large-scale trials, optimization of treatment parameters, and comprehensive investigation of taVNS’s long-term effects and underlying mechanisms. This comprehensive overview positions taVNS as a promising and safe modality for DOC treatment, with a focus on understanding its intricate neurophysiological influence and optimizing its application in clinical settings. |
format | Online Article Text |
id | pubmed-10618368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106183682023-11-02 Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications Wang, Likai Gao, Fei Wang, Zhan Liang, Feng Dai, Yongli Wang, Mengchun Wu, Jingyi Chen, Yaning Yan, Qinjie Wang, Litong Front Neurosci Neuroscience This review provides an in-depth exploration of the mechanisms and applications of transcutaneous auricular vagus nerve stimulation (taVNS) in treating disorders of consciousness (DOC). Beginning with an exploration of the vagus nerve’s role in modulating brain function and consciousness, we then delve into the neuroprotective potential of taVNS demonstrated in animal models. The subsequent sections assess the therapeutic impact of taVNS on human DOC, discussing the safety, tolerability, and various factors influencing the treatment response. Finally, the review identifies the current challenges in taVNS research and outlines future directions, emphasizing the need for large-scale trials, optimization of treatment parameters, and comprehensive investigation of taVNS’s long-term effects and underlying mechanisms. This comprehensive overview positions taVNS as a promising and safe modality for DOC treatment, with a focus on understanding its intricate neurophysiological influence and optimizing its application in clinical settings. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10618368/ /pubmed/37920298 http://dx.doi.org/10.3389/fnins.2023.1286267 Text en Copyright © 2023 Wang, Gao, Wang, Liang, Dai, Wang, Wu, Chen, Yan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wang, Likai Gao, Fei Wang, Zhan Liang, Feng Dai, Yongli Wang, Mengchun Wu, Jingyi Chen, Yaning Yan, Qinjie Wang, Litong Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
title | Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
title_full | Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
title_fullStr | Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
title_full_unstemmed | Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
title_short | Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
title_sort | transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618368/ https://www.ncbi.nlm.nih.gov/pubmed/37920298 http://dx.doi.org/10.3389/fnins.2023.1286267 |
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