Targeting human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia

Acute myeloid leukemia (AML) is a fast-growing and highly fatal blood cancer, and recent research has shown that targeting metabolism may be a promising therapeutic approach for treating AML. One promising target is the human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2), which is involved in...

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Detalles Bibliográficos
Autores principales: Chen, Kun-Chi, Hsiao, I-Hsin, Huang, Yu-Nan, Chou, Yu-Tung, Lin, Yi-Chun, Hsieh, Ju-Yi, Chang, Yung-Lung, Wu, Kang-Hsi, Liu, Guang-Yaw, Hung, Hui-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618384/
https://www.ncbi.nlm.nih.gov/pubmed/37079187
http://dx.doi.org/10.1007/s13402-023-00812-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618384/
https://www.ncbi.nlm.nih.gov/pubmed/37079187
http://dx.doi.org/10.1007/s13402-023-00812-x

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