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Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes

PURPOSE: This study aims to compare the outcomes of repair/redo ileal pouch-anal anastomosis (repair/redo-IPAA) with the conversion of IPAA to continent ileostomy (CI) in an effort to prevent the need for a permanent ileostomy (IS) following IPAA failure. METHODS: This research involved a retrospect...

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Autores principales: Ecker, Nils Karl Josef, Dinh, Christian, Möslein, Gabriela, Ecker, Karl-Wilhelm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618396/
https://www.ncbi.nlm.nih.gov/pubmed/37906299
http://dx.doi.org/10.1007/s00384-023-04555-x
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author Ecker, Nils Karl Josef
Dinh, Christian
Möslein, Gabriela
Ecker, Karl-Wilhelm
author_facet Ecker, Nils Karl Josef
Dinh, Christian
Möslein, Gabriela
Ecker, Karl-Wilhelm
author_sort Ecker, Nils Karl Josef
collection PubMed
description PURPOSE: This study aims to compare the outcomes of repair/redo ileal pouch-anal anastomosis (repair/redo-IPAA) with the conversion of IPAA to continent ileostomy (CI) in an effort to prevent the need for a permanent ileostomy (IS) following IPAA failure. METHODS: This research involved a retrospective analysis of surgical records, employing descriptive statistics and Kaplan-Meier survival analysis. RESULTS: Among 57 patients with an IPAA, up to three revisions were necessary due to complications or complete failure. Ultimately, repair/redo-IPAA preserved the IPAA in 14 patients (24.6%), conversion to CI salvaged the pouch in 21 patients (36.8%), and IS was unavoidable in 22 patients (38.6%). The cumulative probability of requiring conversion surgery was calculated to be 54.0% at 20 years, thereby reducing the cumulative risk of IS to 32.3%. The 20-year cumulative probability of pouch salvage by repair/redo IPAA was only 21.9%. However, this rate increased to 67.7% when conversion procedures were considered. Following repair/redo-IPAA, only 8.3% of patients reported evacuation frequencies of ≤ 4 during the day, and 16.7% were evacuation-free at night. In contrast, after conversion to CI, 98.0% of patients reported a maximum of four evacuations in a 24-h period. After undergoing repair/redo IPAA, between half and two-thirds of patients reported experiencing incontinence or soiling, while complete continence was achieved in all patients following conversion to CI. Notably, the majority of patients expressed overall satisfaction with their respective procedures. A positive correlation was identified between very high subjective satisfaction and positive objective surgical outcomes exclusively in patients who underwent conversion to CI. CONCLUSION: When complications or failure of IPAA occur, conversion to CI emerges as a highly viable alternative to repair/redo IPAA. This conclusion is supported by the observation that patient satisfaction appears to be closely tied to stable surgical outcomes. To reinforce these findings, further prospective studies are warranted.
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spelling pubmed-106183962023-11-02 Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes Ecker, Nils Karl Josef Dinh, Christian Möslein, Gabriela Ecker, Karl-Wilhelm Int J Colorectal Dis Research PURPOSE: This study aims to compare the outcomes of repair/redo ileal pouch-anal anastomosis (repair/redo-IPAA) with the conversion of IPAA to continent ileostomy (CI) in an effort to prevent the need for a permanent ileostomy (IS) following IPAA failure. METHODS: This research involved a retrospective analysis of surgical records, employing descriptive statistics and Kaplan-Meier survival analysis. RESULTS: Among 57 patients with an IPAA, up to three revisions were necessary due to complications or complete failure. Ultimately, repair/redo-IPAA preserved the IPAA in 14 patients (24.6%), conversion to CI salvaged the pouch in 21 patients (36.8%), and IS was unavoidable in 22 patients (38.6%). The cumulative probability of requiring conversion surgery was calculated to be 54.0% at 20 years, thereby reducing the cumulative risk of IS to 32.3%. The 20-year cumulative probability of pouch salvage by repair/redo IPAA was only 21.9%. However, this rate increased to 67.7% when conversion procedures were considered. Following repair/redo-IPAA, only 8.3% of patients reported evacuation frequencies of ≤ 4 during the day, and 16.7% were evacuation-free at night. In contrast, after conversion to CI, 98.0% of patients reported a maximum of four evacuations in a 24-h period. After undergoing repair/redo IPAA, between half and two-thirds of patients reported experiencing incontinence or soiling, while complete continence was achieved in all patients following conversion to CI. Notably, the majority of patients expressed overall satisfaction with their respective procedures. A positive correlation was identified between very high subjective satisfaction and positive objective surgical outcomes exclusively in patients who underwent conversion to CI. CONCLUSION: When complications or failure of IPAA occur, conversion to CI emerges as a highly viable alternative to repair/redo IPAA. This conclusion is supported by the observation that patient satisfaction appears to be closely tied to stable surgical outcomes. To reinforce these findings, further prospective studies are warranted. Springer Berlin Heidelberg 2023-10-31 2023 /pmc/articles/PMC10618396/ /pubmed/37906299 http://dx.doi.org/10.1007/s00384-023-04555-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Ecker, Nils Karl Josef
Dinh, Christian
Möslein, Gabriela
Ecker, Karl-Wilhelm
Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes
title Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes
title_full Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes
title_fullStr Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes
title_full_unstemmed Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes
title_short Comparing continent ileostomy (CI) conversion to repair/redo IPAA: favorable outcomes
title_sort comparing continent ileostomy (ci) conversion to repair/redo ipaa: favorable outcomes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618396/
https://www.ncbi.nlm.nih.gov/pubmed/37906299
http://dx.doi.org/10.1007/s00384-023-04555-x
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