Vascular smooth muscle cell mechanotransduction through serum and glucocorticoid inducible kinase-1 promotes interleukin-6 production and macrophage accumulation in murine hypertension

OBJECTIVE: The objective of this investigation was to demonstrate that in vivo induction of hypertension (HTN) and in vitro cyclic stretch of aortic vascular smooth muscle cells (VSMCs) can cause serum and glucocorticoid-inducible kinase (SGK-1)-dependent production of cytokines to promote macrophag...

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Autores principales: Figueroa, Mario, Hall, SarahRose, Mattia, Victoria, Mendoza, Alex, Brown, Adam, Xiong, Ying, Mukherjee, Rupak, Jones, Jeffrey A., Richardson, William, Ruddy, Jean Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618507/
https://www.ncbi.nlm.nih.gov/pubmed/37920479
http://dx.doi.org/10.1016/j.jvssci.2023.100124

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