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Antigen presentation by B cells enables epitope spreading across an MHC barrier

Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to enter...

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Detalles Bibliográficos
Autores principales:	Fahlquist-Hagert, Cecilia, Wittenborn, Thomas R., Terczyńska-Dyla, Ewa, Kastberg, Kristian Savstrup, Yang, Emily, Rallistan, Alysa Nicole, Markett, Quinton Raymond, Winther, Gudrun, Fonager, Sofie, Voss, Lasse F., Pedersen, Mathias K., van Campen, Nina, Ferapontov, Alexey, Jensen, Lisbeth, Huang, Jinrong, Nieland, John D., van der Poel, Cees E., Palmfeldt, Johan, Carroll, Michael C., Utz, Paul J., Luo, Yonglun, Lin, Lin, Degn, Søren E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618542/ https://www.ncbi.nlm.nih.gov/pubmed/37907556 http://dx.doi.org/10.1038/s41467-023-42541-7

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