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Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements
Fibrosarcoma, originating from fibroblast cells, represents a malignant neoplasm that can manifest across all genders and age groups. Fusion genes are notably prevalent within the landscape of human cancers, particularly within the subtypes of fibrosarcoma, where they exert substantial driving force...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618559/ https://www.ncbi.nlm.nih.gov/pubmed/37920823 http://dx.doi.org/10.3389/fcell.2023.1284428 |
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author | Tang, Xiaodi Hu, Xin Wen, Yang Min, Li |
author_facet | Tang, Xiaodi Hu, Xin Wen, Yang Min, Li |
author_sort | Tang, Xiaodi |
collection | PubMed |
description | Fibrosarcoma, originating from fibroblast cells, represents a malignant neoplasm that can manifest across all genders and age groups. Fusion genes are notably prevalent within the landscape of human cancers, particularly within the subtypes of fibrosarcoma, where they exert substantial driving forces in tumorigenesis. Many fusion genes underlie the pathogenic mechanisms triggering the onset of this disease. Moreover, a close association emerges between the spectrum of fusion gene types and the phenotypic expression of fibrosarcoma, endowing fusion genes not only as promising diagnostic indicators for fibrosarcoma but also as pivotal foundations for its subcategorization. Concurrently, an increasing number of chimeric proteins encoded by fusion genes have been substantiated as specific targets for treating fibrosarcoma, consequently significantly enhancing patient prognoses. This review comprehensively delineates the mechanisms behind fusion gene formation in fibrosarcoma, the lineage of fusion genes, methodologies employed in detecting fusion genes within fibrosarcoma, and the prospects of targeted therapeutic interventions driven by fusion genes within the fibrosarcoma domain. |
format | Online Article Text |
id | pubmed-10618559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106185592023-11-02 Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements Tang, Xiaodi Hu, Xin Wen, Yang Min, Li Front Cell Dev Biol Cell and Developmental Biology Fibrosarcoma, originating from fibroblast cells, represents a malignant neoplasm that can manifest across all genders and age groups. Fusion genes are notably prevalent within the landscape of human cancers, particularly within the subtypes of fibrosarcoma, where they exert substantial driving forces in tumorigenesis. Many fusion genes underlie the pathogenic mechanisms triggering the onset of this disease. Moreover, a close association emerges between the spectrum of fusion gene types and the phenotypic expression of fibrosarcoma, endowing fusion genes not only as promising diagnostic indicators for fibrosarcoma but also as pivotal foundations for its subcategorization. Concurrently, an increasing number of chimeric proteins encoded by fusion genes have been substantiated as specific targets for treating fibrosarcoma, consequently significantly enhancing patient prognoses. This review comprehensively delineates the mechanisms behind fusion gene formation in fibrosarcoma, the lineage of fusion genes, methodologies employed in detecting fusion genes within fibrosarcoma, and the prospects of targeted therapeutic interventions driven by fusion genes within the fibrosarcoma domain. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10618559/ /pubmed/37920823 http://dx.doi.org/10.3389/fcell.2023.1284428 Text en Copyright © 2023 Tang, Hu, Wen and Min. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Tang, Xiaodi Hu, Xin Wen, Yang Min, Li Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
title | Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
title_full | Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
title_fullStr | Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
title_full_unstemmed | Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
title_short | Progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
title_sort | progressive insights into fibrosarcoma diagnosis and treatment: leveraging fusion genes for advancements |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618559/ https://www.ncbi.nlm.nih.gov/pubmed/37920823 http://dx.doi.org/10.3389/fcell.2023.1284428 |
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