Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment

Calcium, an indispensable element in bone tissues, plays a crucial role in various cellular processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in the body presents an opportunity to target calcium homeostasis as a novel strategies for cancer treatment, with...

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Detalles Bibliográficos
Autores principales: Wu, Yilun, Cheng, Min, Jiang, Yi, Zhang, Xin, Li, Jiaxiang, Zhu, Yishen, Yao, Qingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618625/
https://www.ncbi.nlm.nih.gov/pubmed/37920827
http://dx.doi.org/10.1016/j.bioactmat.2023.10.008
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author Wu, Yilun
Cheng, Min
Jiang, Yi
Zhang, Xin
Li, Jiaxiang
Zhu, Yishen
Yao, Qingqiang
author_facet Wu, Yilun
Cheng, Min
Jiang, Yi
Zhang, Xin
Li, Jiaxiang
Zhu, Yishen
Yao, Qingqiang
author_sort Wu, Yilun
collection PubMed
description Calcium, an indispensable element in bone tissues, plays a crucial role in various cellular processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in the body presents an opportunity to target calcium homeostasis as a novel strategies for cancer treatment, with specific advantages in osteosarcoma therapy. In this comprehensive review, we retrospect the calcium biology intersected with cancer progression, highlight the unveiling features of calcium-based biomaterials in regulating both bone homeostasis and cancer development. We also provide an overview of recent breakthroughs in cancer therapy that leverage calcium biomaterials, showcasing their potential to serve as versatile, customizable platforms for osteosarcoma treatment and as reservoirs for supporting bone reconstruction.
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spelling pubmed-106186252023-11-02 Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment Wu, Yilun Cheng, Min Jiang, Yi Zhang, Xin Li, Jiaxiang Zhu, Yishen Yao, Qingqiang Bioact Mater Review Article Calcium, an indispensable element in bone tissues, plays a crucial role in various cellular processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in the body presents an opportunity to target calcium homeostasis as a novel strategies for cancer treatment, with specific advantages in osteosarcoma therapy. In this comprehensive review, we retrospect the calcium biology intersected with cancer progression, highlight the unveiling features of calcium-based biomaterials in regulating both bone homeostasis and cancer development. We also provide an overview of recent breakthroughs in cancer therapy that leverage calcium biomaterials, showcasing their potential to serve as versatile, customizable platforms for osteosarcoma treatment and as reservoirs for supporting bone reconstruction. KeAi Publishing 2023-10-22 /pmc/articles/PMC10618625/ /pubmed/37920827 http://dx.doi.org/10.1016/j.bioactmat.2023.10.008 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wu, Yilun
Cheng, Min
Jiang, Yi
Zhang, Xin
Li, Jiaxiang
Zhu, Yishen
Yao, Qingqiang
Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
title Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
title_full Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
title_fullStr Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
title_full_unstemmed Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
title_short Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
title_sort calcium-based biomaterials: unveiling features and expanding applications in osteosarcoma treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618625/
https://www.ncbi.nlm.nih.gov/pubmed/37920827
http://dx.doi.org/10.1016/j.bioactmat.2023.10.008
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