Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

PURPOSE: The optimal application of maintenance PARP inhibitor therapy for ovarian cancer requires accessible, robust, and rapid testing of homologous recombination deficiency (HRD). However, in many countries, access to HRD testing is problematic and the failure rate is high. We developed an academ...

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Detalles Bibliográficos
Autores principales: Leman, Raphaël, Muller, Etienne, Legros, Angelina, Goardon, Nicolas, Chentli, Imène, Atkinson, Alexandre, Tranchant, Aurore, Castera, Laurent, Krieger, Sophie, Ricou, Agathe, Boulouard, Flavie, Joly, Florence, Boucly, Romain, Dumont, Aurélie, Basset, Noémie, Coulet, Florence, Chevalier, Louise-Marie, Rouleau, Etienne, Leitner, Katharina, González-Martin, Antonio, Gargiulo, Piera, Lück, Hans-Joachim, Genestie, Catherine, Ray-Coquard, Isabelle, Pujade-Lauraine, Eric, Vaur, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618649/
https://www.ncbi.nlm.nih.gov/pubmed/37756555
http://dx.doi.org/10.1158/1078-0432.CCR-23-0898

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