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Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function

Natural killer (NK) cells are frequently expanded for the clinic using irradiated, engineered K562 feeder cells expressing a core transgene set of membrane-bound (mb) IL15 and/or mbIL21 together with 41BBL. Prior comparisons of mbIL15 to mbIL21 for NK expansion lack comparisons of key attributes of...

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Detalles Bibliográficos
Autores principales:	Zhang, Caimei, Kadu, Siddhant, Xiao, Yansen, Johnson, Omar, Kelly, Andre, O'Connor, Roddy S., Lai, Meizan, Kong, Hong, Srivatsa, Sriram, Tai, Victoria, Greenblatt, Eli, Holmes, Matthew, Riley, James L., June, Carl H., Sheppard, Neil C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618651/ https://www.ncbi.nlm.nih.gov/pubmed/37649085 http://dx.doi.org/10.1158/2326-6066.CIR-23-0151

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