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Targeted Nanofitin-drug Conjugates Achieve Efficient Tumor Delivery and Therapeutic Effect in an EGFR(pos) Mouse Xenograft Model

Adjusting the molecular size, the valency and the pharmacokinetics of drug conjugates are as many leverages to improve their therapeutic window, notably by affecting tumor penetration, renal clearance, and short systemic exposure. In that regard, small tumor-targeting ligands are gaining attention....

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Detalles Bibliográficos
Autores principales:	Huet, Simon, Zeisser Labouebe, Magali, Castro, Rute, Jacquot, Perrine, Pedrault, Jessy, Viollet, Sébastien, Van Simaeys, Gaetan, Doumont, Gilles, Larbanoix, Lionel, Zindy, Egor, Cunha, António E., Scapozza, Leonardo, Cinier, Mathieu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Large Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618730/ https://www.ncbi.nlm.nih.gov/pubmed/37578807 http://dx.doi.org/10.1158/1535-7163.MCT-22-0805

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