USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma

In this study, we identify USP1 as a transcriptional target of EWS::FLI1 and demonstrate the requisite function of USP1 in Ewing sarcoma (EWS) cell survival in response to endogenous replication stress. EWS::FLI1 oncogenic transcription factor drives most EWS, a pediatric bone cancer. EWS cells disp...

Descripción completa

Detalles Bibliográficos
Autores principales: Mallard, Halle J., Wan, Shibiao, Nidhi, Prakriti, Hanscom-Trofy, Yvan D., Mohapatra, Bhopal, Woods, Nicholas T., Lopez-Guerrero, Jose Antonio, Llombart-Bosch, Antonio, Machado, Isidro, Scotlandi, Katia, Kreiling, Natasha F., Perry, Megan C., Mirza, Sameer, Coulter, Donald W., Band, Vimla, Band, Hamid, Ghosal, Gargi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Genome Maintenance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618738/
https://www.ncbi.nlm.nih.gov/pubmed/37478161
http://dx.doi.org/10.1158/1541-7786.MCR-23-0323

Ejemplares similares

Ejemplares similares