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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

Phosphoinositide 3-kinase α (PIK3CA) is one of the most mutated genes across cancers, especially breast, gynecologic, and head and neck squamous cell carcinoma tumors. Mutations occur throughout the gene, but hotspot mutations in the helical and kinase domains predominate. The therapeutic benefit of...

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Detalles Bibliográficos
Autores principales:	Buckbinder, Leonard, St. Jean, David J., Tieu, Trang, Ladd, Brendon, Hilbert, Brendan, Wang, Weixue, Alltucker, Jacob T., Manimala, Samantha, Kryukov, Gregory V., Brooijmans, Natasja, Dowdell, Gregory, Jonsson, Philip, Huff, Michael, Guzman-Perez, Angel, Jackson, Erica L., Goncalves, Marcus D., Stuart, Darrin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618743/ https://www.ncbi.nlm.nih.gov/pubmed/37623743 http://dx.doi.org/10.1158/2159-8290.CD-23-0396

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