The Distribution of Cervical Human Papillomavirus Infection Among Chinese Adult Women

BACKGROUND: The characteristics and genotypic distribution of human papillomavirus (HPV) infection differ in different countries and regions. The purpose of this study was to analyze the distribution of 27 HPV subtypes among adult women receiving health examinations in Jinan, China. METHODS: A retrospective analysis was performed to analyze HPV subtype infection among adult women who underwent cervical cancer screening from January 1, 2020, to December 31, 2020. RESULTS: Among 4746 women receiving HPV testing, 682 cases were positive, representing 14.4% of patients. In total, 514 cases were infected by a single HPV subtype (75.4%), 115 cases had dual infections (16.9%), and 53 cases had multiple infections (7.7%). Among the 682 cases of HPV infection, 503 cases (73.8%) were high-risk HPV infections. The most common high-risk HPV strains were HPV 52 (23.3%), HPV 16 (13.5%), and HPV 58 (12.7%). Low-risk HPV strains infected 179 cases (26.2%). The most common genotypes were HPV 61 (25.7%), HPV 81 (21.2%), and HPV 55 (15.6%). CONCLUSION: The HPV infection rate in healthy women was high, and the mixed infection rate was as high as 24.6%, highlighting the need for increased attention to this virus.