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50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress. Even a minimal redox module comprised of just 12 (ROS & antioxidant) inputs and 3 outputs (oxidative damage,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618833/ https://www.ncbi.nlm.nih.gov/pubmed/37875063 http://dx.doi.org/10.1016/j.redox.2023.102936 |
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author | Cobley, James N. |
author_facet | Cobley, James N. |
author_sort | Cobley, James N. |
collection | PubMed |
description | Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress. Even a minimal redox module comprised of just 12 (ROS & antioxidant) inputs and 3 outputs (oxidative damage, cysteine-dependent redox-regulation, or both) yields over half a million “shades” of oxidative stress. The present paper proposes the novel hypothesis that: state-specific shades of oxidative stress, such as a discrete disease, are associated with distinct tell-tale cysteine oxidation patterns. The patterns are encoded by many parameters, from the identity of the oxidised proteins, the cysteine oxidation type, and magnitude. The hypothesis is conceptually grounded in distinct ROS and antioxidant inputs coalescing to produce unique cysteine oxidation outputs. And considers the potential biological significance of the holistic cysteine oxidation outputs. The literature supports the existence of state-specific cysteine oxidation patterns. Measuring and manipulating these patterns offer promising avenues for advancing oxidative stress research. The pattern inspired hypothesis provides a framework for understanding the complex biochemical nature of state-specific oxidative stress. |
format | Online Article Text |
id | pubmed-10618833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106188332023-11-02 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis Cobley, James N. Redox Biol Research Paper Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress. Even a minimal redox module comprised of just 12 (ROS & antioxidant) inputs and 3 outputs (oxidative damage, cysteine-dependent redox-regulation, or both) yields over half a million “shades” of oxidative stress. The present paper proposes the novel hypothesis that: state-specific shades of oxidative stress, such as a discrete disease, are associated with distinct tell-tale cysteine oxidation patterns. The patterns are encoded by many parameters, from the identity of the oxidised proteins, the cysteine oxidation type, and magnitude. The hypothesis is conceptually grounded in distinct ROS and antioxidant inputs coalescing to produce unique cysteine oxidation outputs. And considers the potential biological significance of the holistic cysteine oxidation outputs. The literature supports the existence of state-specific cysteine oxidation patterns. Measuring and manipulating these patterns offer promising avenues for advancing oxidative stress research. The pattern inspired hypothesis provides a framework for understanding the complex biochemical nature of state-specific oxidative stress. Elsevier 2023-10-17 /pmc/articles/PMC10618833/ /pubmed/37875063 http://dx.doi.org/10.1016/j.redox.2023.102936 Text en © 2023 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Paper Cobley, James N. 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis |
title | 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis |
title_full | 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis |
title_fullStr | 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis |
title_full_unstemmed | 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis |
title_short | 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis |
title_sort | 50 shades of oxidative stress: a state-specific cysteine redox pattern hypothesis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618833/ https://www.ncbi.nlm.nih.gov/pubmed/37875063 http://dx.doi.org/10.1016/j.redox.2023.102936 |
work_keys_str_mv | AT cobleyjamesn 50shadesofoxidativestressastatespecificcysteineredoxpatternhypothesis |