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50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis

Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress. Even a minimal redox module comprised of just 12 (ROS & antioxidant) inputs and 3 outputs (oxidative damage,...

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Detalles Bibliográficos
Autor principal: Cobley, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618833/
https://www.ncbi.nlm.nih.gov/pubmed/37875063
http://dx.doi.org/10.1016/j.redox.2023.102936
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author Cobley, James N.
author_facet Cobley, James N.
author_sort Cobley, James N.
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description Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress. Even a minimal redox module comprised of just 12 (ROS & antioxidant) inputs and 3 outputs (oxidative damage, cysteine-dependent redox-regulation, or both) yields over half a million “shades” of oxidative stress. The present paper proposes the novel hypothesis that: state-specific shades of oxidative stress, such as a discrete disease, are associated with distinct tell-tale cysteine oxidation patterns. The patterns are encoded by many parameters, from the identity of the oxidised proteins, the cysteine oxidation type, and magnitude. The hypothesis is conceptually grounded in distinct ROS and antioxidant inputs coalescing to produce unique cysteine oxidation outputs. And considers the potential biological significance of the holistic cysteine oxidation outputs. The literature supports the existence of state-specific cysteine oxidation patterns. Measuring and manipulating these patterns offer promising avenues for advancing oxidative stress research. The pattern inspired hypothesis provides a framework for understanding the complex biochemical nature of state-specific oxidative stress.
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spelling pubmed-106188332023-11-02 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis Cobley, James N. Redox Biol Research Paper Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress. Even a minimal redox module comprised of just 12 (ROS & antioxidant) inputs and 3 outputs (oxidative damage, cysteine-dependent redox-regulation, or both) yields over half a million “shades” of oxidative stress. The present paper proposes the novel hypothesis that: state-specific shades of oxidative stress, such as a discrete disease, are associated with distinct tell-tale cysteine oxidation patterns. The patterns are encoded by many parameters, from the identity of the oxidised proteins, the cysteine oxidation type, and magnitude. The hypothesis is conceptually grounded in distinct ROS and antioxidant inputs coalescing to produce unique cysteine oxidation outputs. And considers the potential biological significance of the holistic cysteine oxidation outputs. The literature supports the existence of state-specific cysteine oxidation patterns. Measuring and manipulating these patterns offer promising avenues for advancing oxidative stress research. The pattern inspired hypothesis provides a framework for understanding the complex biochemical nature of state-specific oxidative stress. Elsevier 2023-10-17 /pmc/articles/PMC10618833/ /pubmed/37875063 http://dx.doi.org/10.1016/j.redox.2023.102936 Text en © 2023 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Paper
Cobley, James N.
50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
title 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
title_full 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
title_fullStr 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
title_full_unstemmed 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
title_short 50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
title_sort 50 shades of oxidative stress: a state-specific cysteine redox pattern hypothesis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618833/
https://www.ncbi.nlm.nih.gov/pubmed/37875063
http://dx.doi.org/10.1016/j.redox.2023.102936
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