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VIP interneurons regulate cortical size tuning and visual perception
Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping circuit operation according to behavioral context. A specialized population of interneurons that co-express vasoactive intestinal peptides (VIP-INs)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618959/ https://www.ncbi.nlm.nih.gov/pubmed/37682710 http://dx.doi.org/10.1016/j.celrep.2023.113088 |
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author | Ferguson, Katie A. Salameh, Jenna Alba, Christopher Selwyn, Hannah Barnes, Clayton Lohani, Sweyta Cardin, Jessica A. |
author_facet | Ferguson, Katie A. Salameh, Jenna Alba, Christopher Selwyn, Hannah Barnes, Clayton Lohani, Sweyta Cardin, Jessica A. |
author_sort | Ferguson, Katie A. |
collection | PubMed |
description | Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping circuit operation according to behavioral context. A specialized population of interneurons that co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs and pyramidal neurons (PNs). Although state-dependent modulation of VIP-INs has been extensively studied, their role in regulating sensory processing is less well understood. We examined the impact of VIP-INs in the primary visual cortex of awake behaving mice. Loss of VIP-IN activity alters the behavioral state-dependent modulation of somatostatin-expressing INs (SST-INs) but not PNs. In contrast, reduced VIP-IN activity globally disrupts visual feature selectivity for stimulus size. Moreover, the impact of VIP-INs on perceptual behavior varies with context and is more acute for small than large visual cues. VIP-INs thus contribute to both state-dependent modulation of cortical activity and sensory context-dependent perceptual performance. |
format | Online Article Text |
id | pubmed-10618959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-106189592023-11-01 VIP interneurons regulate cortical size tuning and visual perception Ferguson, Katie A. Salameh, Jenna Alba, Christopher Selwyn, Hannah Barnes, Clayton Lohani, Sweyta Cardin, Jessica A. Cell Rep Article Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping circuit operation according to behavioral context. A specialized population of interneurons that co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs and pyramidal neurons (PNs). Although state-dependent modulation of VIP-INs has been extensively studied, their role in regulating sensory processing is less well understood. We examined the impact of VIP-INs in the primary visual cortex of awake behaving mice. Loss of VIP-IN activity alters the behavioral state-dependent modulation of somatostatin-expressing INs (SST-INs) but not PNs. In contrast, reduced VIP-IN activity globally disrupts visual feature selectivity for stimulus size. Moreover, the impact of VIP-INs on perceptual behavior varies with context and is more acute for small than large visual cues. VIP-INs thus contribute to both state-dependent modulation of cortical activity and sensory context-dependent perceptual performance. 2023-09-26 2023-09-08 /pmc/articles/PMC10618959/ /pubmed/37682710 http://dx.doi.org/10.1016/j.celrep.2023.113088 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Ferguson, Katie A. Salameh, Jenna Alba, Christopher Selwyn, Hannah Barnes, Clayton Lohani, Sweyta Cardin, Jessica A. VIP interneurons regulate cortical size tuning and visual perception |
title | VIP interneurons regulate cortical size tuning and visual perception |
title_full | VIP interneurons regulate cortical size tuning and visual perception |
title_fullStr | VIP interneurons regulate cortical size tuning and visual perception |
title_full_unstemmed | VIP interneurons regulate cortical size tuning and visual perception |
title_short | VIP interneurons regulate cortical size tuning and visual perception |
title_sort | vip interneurons regulate cortical size tuning and visual perception |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618959/ https://www.ncbi.nlm.nih.gov/pubmed/37682710 http://dx.doi.org/10.1016/j.celrep.2023.113088 |
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