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Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618972/ https://www.ncbi.nlm.nih.gov/pubmed/37920406 http://dx.doi.org/10.1136/gpsych-2023-101127 |
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author | Zhang, Wenlei Zhou, Jiahui Su, Hang Zhang, Xiaocheng Song, Weichen Wang, Zijing Tang, Chengjie Uludağ, Kadir Zhao, Min Xiong, Zhi-Qi Zhai, Rongwei Jiang, Haifeng |
author_facet | Zhang, Wenlei Zhou, Jiahui Su, Hang Zhang, Xiaocheng Song, Weichen Wang, Zijing Tang, Chengjie Uludağ, Kadir Zhao, Min Xiong, Zhi-Qi Zhai, Rongwei Jiang, Haifeng |
author_sort | Zhang, Wenlei |
collection | PubMed |
description | BACKGROUND: Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals. AIMS: The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys. METHODS: This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys. RESULTS: Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration. CONCLUSIONS: These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period. |
format | Online Article Text |
id | pubmed-10618972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-106189722023-11-02 Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys Zhang, Wenlei Zhou, Jiahui Su, Hang Zhang, Xiaocheng Song, Weichen Wang, Zijing Tang, Chengjie Uludağ, Kadir Zhao, Min Xiong, Zhi-Qi Zhai, Rongwei Jiang, Haifeng Gen Psychiatr Original Research BACKGROUND: Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals. AIMS: The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys. METHODS: This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys. RESULTS: Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration. CONCLUSIONS: These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period. BMJ Publishing Group 2023-10-31 /pmc/articles/PMC10618972/ /pubmed/37920406 http://dx.doi.org/10.1136/gpsych-2023-101127 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Zhang, Wenlei Zhou, Jiahui Su, Hang Zhang, Xiaocheng Song, Weichen Wang, Zijing Tang, Chengjie Uludağ, Kadir Zhao, Min Xiong, Zhi-Qi Zhai, Rongwei Jiang, Haifeng Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
title | Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
title_full | Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
title_fullStr | Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
title_full_unstemmed | Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
title_short | Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
title_sort | repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618972/ https://www.ncbi.nlm.nih.gov/pubmed/37920406 http://dx.doi.org/10.1136/gpsych-2023-101127 |
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