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Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018
OBJECTIVE: The pathogenesis of depression is related to immune inflammatory response. Atherogenic coefficient (AC) is an important indicator of lipid abnormalities, which can lead to immune inflammatory responses. However, no study has investigated the relationship between AC and depression in adult...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619029/ https://www.ncbi.nlm.nih.gov/pubmed/37899167 http://dx.doi.org/10.1136/bmjopen-2023-074001 |
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author | Zhang, Lu Yin, Jiahui Sun, Haiyang Yang, Jiguo Liu, Yuanxiang |
author_facet | Zhang, Lu Yin, Jiahui Sun, Haiyang Yang, Jiguo Liu, Yuanxiang |
author_sort | Zhang, Lu |
collection | PubMed |
description | OBJECTIVE: The pathogenesis of depression is related to immune inflammatory response. Atherogenic coefficient (AC) is an important indicator of lipid abnormalities, which can lead to immune inflammatory responses. However, no study has investigated the relationship between AC and depression in adult Americans. Therefore, we investigated this relationship. DESIGN: This study used a cross-sectional design. SETTING: The National Health and Nutrition Examination Survey (2005–2018) data were used for this study. PARTICIPANTS: A total of 32 502 participants aged 20 years or older who had complete information for AC and depression were included in this study. PRIMARY AND SECONDARY OUTCOME MEASURES: Depressive symptoms were assessed using the nine-item version of the Patient Health Questionnaire (PHQ-9), with a cut-off point of 9/10 indicating likely depression cases. Weighted logistic regression analyses and the smooth curve fittings were performed to explore the association between AC and depression. RESULTS: After adjusting for potential confounders, a single unit increase in AC was associated with a 3% increase in the prevalence of depression (HR=1.03, 95% CI=1.00 to 1.06, p=0.039). The relationship between AC and depression was more obvious in females. CONCLUSIONS: The AC is positively associated with depression. |
format | Online Article Text |
id | pubmed-10619029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-106190292023-11-02 Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 Zhang, Lu Yin, Jiahui Sun, Haiyang Yang, Jiguo Liu, Yuanxiang BMJ Open Mental Health OBJECTIVE: The pathogenesis of depression is related to immune inflammatory response. Atherogenic coefficient (AC) is an important indicator of lipid abnormalities, which can lead to immune inflammatory responses. However, no study has investigated the relationship between AC and depression in adult Americans. Therefore, we investigated this relationship. DESIGN: This study used a cross-sectional design. SETTING: The National Health and Nutrition Examination Survey (2005–2018) data were used for this study. PARTICIPANTS: A total of 32 502 participants aged 20 years or older who had complete information for AC and depression were included in this study. PRIMARY AND SECONDARY OUTCOME MEASURES: Depressive symptoms were assessed using the nine-item version of the Patient Health Questionnaire (PHQ-9), with a cut-off point of 9/10 indicating likely depression cases. Weighted logistic regression analyses and the smooth curve fittings were performed to explore the association between AC and depression. RESULTS: After adjusting for potential confounders, a single unit increase in AC was associated with a 3% increase in the prevalence of depression (HR=1.03, 95% CI=1.00 to 1.06, p=0.039). The relationship between AC and depression was more obvious in females. CONCLUSIONS: The AC is positively associated with depression. BMJ Publishing Group 2023-10-29 /pmc/articles/PMC10619029/ /pubmed/37899167 http://dx.doi.org/10.1136/bmjopen-2023-074001 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Mental Health Zhang, Lu Yin, Jiahui Sun, Haiyang Yang, Jiguo Liu, Yuanxiang Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 |
title | Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 |
title_full | Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 |
title_fullStr | Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 |
title_full_unstemmed | Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 |
title_short | Association between atherogenic coefficient and depression in US adults: a cross-sectional study with data from National Health and Nutrition Examination Survey 2005–2018 |
title_sort | association between atherogenic coefficient and depression in us adults: a cross-sectional study with data from national health and nutrition examination survey 2005–2018 |
topic | Mental Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619029/ https://www.ncbi.nlm.nih.gov/pubmed/37899167 http://dx.doi.org/10.1136/bmjopen-2023-074001 |
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