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Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report
Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) encompasses the timely diagnosis and adequate treatment of the superficial group A Streptococcus (GAS) infections pharyngitis and impetigo. GAS is the only known inciting agent in the pathophysiology of the disease....
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619102/ https://www.ncbi.nlm.nih.gov/pubmed/37914184 http://dx.doi.org/10.1136/bmjgh-2023-012356 |
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author | Rwebembera, Joselyn Cannon, Jeffrey W Sanyahumbi, Amy Sotoodehnia, Nona Taubert, Kathryn Yilgwan, Christopher Sabo Bukhman, Gene Masterson, Mary Bruno, Fernando P Bowen, Asha Dale, James B Engel, Mark E Beaton, Andrea Van Beneden, Chris |
author_facet | Rwebembera, Joselyn Cannon, Jeffrey W Sanyahumbi, Amy Sotoodehnia, Nona Taubert, Kathryn Yilgwan, Christopher Sabo Bukhman, Gene Masterson, Mary Bruno, Fernando P Bowen, Asha Dale, James B Engel, Mark E Beaton, Andrea Van Beneden, Chris |
author_sort | Rwebembera, Joselyn |
collection | PubMed |
description | Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) encompasses the timely diagnosis and adequate treatment of the superficial group A Streptococcus (GAS) infections pharyngitis and impetigo. GAS is the only known inciting agent in the pathophysiology of the disease. However, sufficient evidence indicates that the uptake and delivery of primary prevention approaches in RHD-endemic regions are significantly suboptimal. This report presents expert deliberations on priority research and implementation opportunities for primary prevention of ARF/RHD that were developed as part of a workshop convened by the US National Heart, Lung, and Blood Institute in November 2021. The opportunities identified by the Primary Prevention Working Group encompass epidemiological, laboratory, clinical, implementation and dissemination research domains and are anchored on five pillars including: (A) to gain a better understanding of superficial GAS infection epidemiology to guide programmes and policies; (B) to improve diagnosis of superficial GAS infections in RHD endemic settings; (C) to develop scalable and sustainable models for delivery of primary prevention; (D) to understand potential downstream effects of the scale-up of primary prevention and (E) to develop and conduct economic evaluations of primary prevention strategies in RHD endemic settings. In view of the multisectoral stakeholders in primary prevention strategies, we emphasise the need for community co-design and government engagement, especially in the implementation and dissemination research arena. We present these opportunities as a reference point for research organisations and sponsors who aim to contribute to the increasing momentum towards the global control and prevention of RHD. |
format | Online Article Text |
id | pubmed-10619102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-106191022023-11-02 Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report Rwebembera, Joselyn Cannon, Jeffrey W Sanyahumbi, Amy Sotoodehnia, Nona Taubert, Kathryn Yilgwan, Christopher Sabo Bukhman, Gene Masterson, Mary Bruno, Fernando P Bowen, Asha Dale, James B Engel, Mark E Beaton, Andrea Van Beneden, Chris BMJ Glob Health Analysis Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) encompasses the timely diagnosis and adequate treatment of the superficial group A Streptococcus (GAS) infections pharyngitis and impetigo. GAS is the only known inciting agent in the pathophysiology of the disease. However, sufficient evidence indicates that the uptake and delivery of primary prevention approaches in RHD-endemic regions are significantly suboptimal. This report presents expert deliberations on priority research and implementation opportunities for primary prevention of ARF/RHD that were developed as part of a workshop convened by the US National Heart, Lung, and Blood Institute in November 2021. The opportunities identified by the Primary Prevention Working Group encompass epidemiological, laboratory, clinical, implementation and dissemination research domains and are anchored on five pillars including: (A) to gain a better understanding of superficial GAS infection epidemiology to guide programmes and policies; (B) to improve diagnosis of superficial GAS infections in RHD endemic settings; (C) to develop scalable and sustainable models for delivery of primary prevention; (D) to understand potential downstream effects of the scale-up of primary prevention and (E) to develop and conduct economic evaluations of primary prevention strategies in RHD endemic settings. In view of the multisectoral stakeholders in primary prevention strategies, we emphasise the need for community co-design and government engagement, especially in the implementation and dissemination research arena. We present these opportunities as a reference point for research organisations and sponsors who aim to contribute to the increasing momentum towards the global control and prevention of RHD. BMJ Publishing Group 2023-10-31 /pmc/articles/PMC10619102/ /pubmed/37914184 http://dx.doi.org/10.1136/bmjgh-2023-012356 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Analysis Rwebembera, Joselyn Cannon, Jeffrey W Sanyahumbi, Amy Sotoodehnia, Nona Taubert, Kathryn Yilgwan, Christopher Sabo Bukhman, Gene Masterson, Mary Bruno, Fernando P Bowen, Asha Dale, James B Engel, Mark E Beaton, Andrea Van Beneden, Chris Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report |
title | Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report |
title_full | Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report |
title_fullStr | Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report |
title_full_unstemmed | Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report |
title_short | Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report |
title_sort | research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a national heart, lung, and blood institute workshop report |
topic | Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619102/ https://www.ncbi.nlm.nih.gov/pubmed/37914184 http://dx.doi.org/10.1136/bmjgh-2023-012356 |
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