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Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway

BACKGROUND: Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, ICB alone has demonstrated only benefit in a small subset of patients with breast cancer. Recent studies have shown that agents targeting DNA damage response improve the efficacy of ICB and promote cytosolic D...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Dai, Hui, Huo, Lei, Burks, Jared K, McGrail, Daniel J, Lin, Shiaw-Yih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619126/ https://www.ncbi.nlm.nih.gov/pubmed/37907220 http://dx.doi.org/10.1136/jitc-2023-007560

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