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The catechol moiety of obafluorin is essential for antibacterial activity

Obafluorin is a Pseudomonas fluorescens antibacterial natural product that inhibits threonyl-tRNA synthetase (ThrRS). It acts as a broad-spectrum antibiotic against a range of clinically relevant pathogens and comprises a strained β-lactone ring decorated with catechol and 4-nitro-benzyl moieties. T...

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Detalles Bibliográficos
Autores principales:	Batey, Sibyl F. D., Davie, Melissa J., Hems, Edward S., Liston, Jonathon D., Scott, Thomas A., Alt, Silke, Francklyn, Christopher S., Wilkinson, Barrie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619133/ https://www.ncbi.nlm.nih.gov/pubmed/37920400 http://dx.doi.org/10.1039/d3cb00127j

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