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A strategy for orthogonal deubiquitination using a bump-and-hole approach

We have successfully applied a bump-and-hole approach to establish orthogonal deubiquitination in which a ubiquitin substrate variant is specifically targeted by an engineered deubiquitinating enzyme (DUB). This makes it possibe to selectively observe and measure a single type of DUB activity in liv...

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Detalles Bibliográficos
Autores principales:	Suzuki, Takumi, Utsugi, Yuki, Yamanaka, Satoshi, Takahashi, Hirotaka, Sato, Yusuke, Sawasaki, Tatsuya, Miyamae, Yusaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619139/ https://www.ncbi.nlm.nih.gov/pubmed/37920396 http://dx.doi.org/10.1039/d3cb00095h

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