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Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment

Vaccination, for centuries, has been a potent preventive technique to treat morbidities. The messenger RNA (mRNA) vaccine technology is an innovative biomedical approach utilized in developing antigen-specific vaccines that can generate adaptive immune responses, triggering both humoral and cellular...

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Autores principales: Ankrah, Paa Kwesi, Ilesanmi, Ajibola, Akinyemi, Amos O, Lasehinde, Victor, Adurosakin, Oluwapelumi E, Ajayi, Oluwatobi H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619190/
https://www.ncbi.nlm.nih.gov/pubmed/37920621
http://dx.doi.org/10.7759/cureus.46354
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author Ankrah, Paa Kwesi
Ilesanmi, Ajibola
Akinyemi, Amos O
Lasehinde, Victor
Adurosakin, Oluwapelumi E
Ajayi, Oluwatobi H
author_facet Ankrah, Paa Kwesi
Ilesanmi, Ajibola
Akinyemi, Amos O
Lasehinde, Victor
Adurosakin, Oluwapelumi E
Ajayi, Oluwatobi H
author_sort Ankrah, Paa Kwesi
collection PubMed
description Vaccination, for centuries, has been a potent preventive technique to treat morbidities. The messenger RNA (mRNA) vaccine technology is an innovative biomedical approach utilized in developing antigen-specific vaccines that can generate adaptive immune responses, triggering both humoral and cellular immunity to enhance the body's defense against specific infections. This review provides a comprehensive, comparative analysis of mRNA vaccine technology and conventional vaccines by focusing on the structures, components, and classifications. An exploratory analysis of the similarities and differences between mRNA vaccine technology and live-attenuated vaccines highlights the mechanisms by which mRNA vaccines elicit immune responses. This review extensively discusses the production, stability, synthesis, and delivery processes associated with mRNA vaccines, showcasing the advancements and technological superiority of this approach over conventional vaccine technologies. Additionally, the potential of mRNA vaccine technology as a potent alternative for the development of vaccine candidates targeting HIV and cancer is examined.
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spelling pubmed-106191902023-11-02 Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment Ankrah, Paa Kwesi Ilesanmi, Ajibola Akinyemi, Amos O Lasehinde, Victor Adurosakin, Oluwapelumi E Ajayi, Oluwatobi H Cureus Allergy/Immunology Vaccination, for centuries, has been a potent preventive technique to treat morbidities. The messenger RNA (mRNA) vaccine technology is an innovative biomedical approach utilized in developing antigen-specific vaccines that can generate adaptive immune responses, triggering both humoral and cellular immunity to enhance the body's defense against specific infections. This review provides a comprehensive, comparative analysis of mRNA vaccine technology and conventional vaccines by focusing on the structures, components, and classifications. An exploratory analysis of the similarities and differences between mRNA vaccine technology and live-attenuated vaccines highlights the mechanisms by which mRNA vaccines elicit immune responses. This review extensively discusses the production, stability, synthesis, and delivery processes associated with mRNA vaccines, showcasing the advancements and technological superiority of this approach over conventional vaccine technologies. Additionally, the potential of mRNA vaccine technology as a potent alternative for the development of vaccine candidates targeting HIV and cancer is examined. Cureus 2023-10-02 /pmc/articles/PMC10619190/ /pubmed/37920621 http://dx.doi.org/10.7759/cureus.46354 Text en Copyright © 2023, Ankrah et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Allergy/Immunology
Ankrah, Paa Kwesi
Ilesanmi, Ajibola
Akinyemi, Amos O
Lasehinde, Victor
Adurosakin, Oluwapelumi E
Ajayi, Oluwatobi H
Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment
title Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment
title_full Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment
title_fullStr Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment
title_full_unstemmed Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment
title_short Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment
title_sort clinical analysis and applications of mrna vaccines in infectious diseases and cancer treatment
topic Allergy/Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619190/
https://www.ncbi.nlm.nih.gov/pubmed/37920621
http://dx.doi.org/10.7759/cureus.46354
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