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KRAS(G12C) inhibition using MRTX1257: a novel radio-sensitizing partner

BACKGROUND: KRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers including non-small cell lung cancer (NSCLC) and colorectal cancer. Although KRAS was considered undruggable until recently, several KRAS inhibitors h...

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Detalles Bibliográficos
Autores principales:	Laurent, Pierre-Antoine, Milic, Marina, Quevrin, Clément, Meziani, Lydia, Liu, Winchygn, Morel, Daphné, Signolle, Nicolas, Clémenson, Céline, Levy, Antonin, Mondini, Michele, Deutsch, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619254/ https://www.ncbi.nlm.nih.gov/pubmed/37907934 http://dx.doi.org/10.1186/s12967-023-04619-0

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